Table 1.
Characteristics of PEAR Follow-Up Study Participants at Baseline and at Follow-up
| Characteristica | Baselineb (n=40) |
Follow-up (n=40) |
P valuec |
|---|---|---|---|
| PEAR participants | 29 (73%) | - | - |
| Arm 1 (HCTZ monotherapy) | 13 (33%) | - | - |
| PEAR-2 participants | 11 (27%) | - | - |
| Gender (female) | 24 (60%) | - | - |
| Race (Caucasian) | 29 (73%) | - | - |
| Weight (kg), mean (SD) | 89.8 (17.7) | 91.7 (17.3) | 0.09 |
| Body mass index (kg/m2), mean (SD) | 31.1 (5.6) | 31.8 (5.4) | 0.09 |
| Waist circumference (cm), mean (SD) | 98 (14) | 102 (16) | 0.002 |
| Abdominal obesityd | 22 (55%) | 27 (68%) | 0.03 |
| SBP, mean (SD)e | 142 (16) | 131 (14) | 0.003 |
| DBP, mean (SD)e | 89 (9) | 83 (10) | 0.02 |
| Consumes alcoholic beverages | 18 (45%) | 22 (55%) | 0.18 |
| Drinks per week, mean (SD) | 5 (7) | 8 (10) | 0.04 |
| Current smoker | 10 (23%) | 7 (16%) | 0.08 |
| Statin treatment | 4 (9%) | 9 (23%) | 0.06 |
| Fasting Glucose (mg/dL), mean (SD) | 91 (12) | 94 (13) | 0.16 |
| Total cholesterol (mg/dL), mean (SD) | 198 (40) | 200 (40) | 0.63 |
| LDL cholesterol (mg/dL), mean (SD) | 122 (36) | 117 (36) | 0.35 |
| HDL cholesterol (mg/dL), mean (SD) | 45 (14) | 52 (17) | <0.0001 |
| Triglycerides (mg/dL), mean (SD) | 154 (121) | 157 (89) | 0.59 |
| Serum potassium (mEq/L), mean (SD) | 4.49 (0.48) | 4.18 (0.49) | 0.003 |
| Uric acid (mg/dL), mean (SD) | 5.9 (1.5) | 6.6 (1.6) | <0.0001 |
| Insulin (µU/mL), mean (SD) | 15.8 (12.6) | 15.2 (10.2) | 0.85 |
| HOMA, mean (SD) | 2.73 (1.79) | 3.32 (2.58) | 0.15 |
| Impaired fasting glucosef | 11 (28%) | 11 (28%) | 0.99 |
SD indicates standard deviation; kg, kilograms; kg/m2, kilograms per meter squared; cm, centimeters, SBP, systolic blood pressure; DBP, diastolic blood pressure; mg/dL, milligrams per deciliter; LDL, low density lipoprotein; HDL, high density lipoprotein; mEq/L, milliequivalents per liter; microunits per milliliter, µU/mL; HOMA, homeostatic model assessment.
Values indicate no. (%) unless otherwise stated.
Baseline is defined as start of thiazide diuretic treatment during PEAR or PEAR-2.
P value indicates paired t-tests or McNemar’s tests for difference between baseline and follow-up.
Abdominal obesity defined as waist circumference ≥88.9 centimeters for females or ≥101.6 centimeters for males.
Average of home BP measurements for baseline and three clinic BP measurements for follow-up study visit.
Impaired fasting glucose defined as fasting glucose ≥ 100 mg/dL.