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A scheme depicting the radiotracer targeting in a lung cancer cell. 18F-FDG (1) uptake into the cell through the glucose transporter results in 18F-FDG-6-phosphate (2) in the cytoplasm as a measure of glucose metabolic rate of the tumor cell. 18F-Nifene (3) binding to the cell-membrane bound α4β2 nicotinic receptor measures the overexpression of the receptor in the tumor cell. 18F-FAHA (4) uptake in the nucleus measures histone deacetylase upregulation in the tumor cell.
