Table 1.
Quantitation of CT and PET Imaging in NNK-treated A/J Mice
| Study | In Vivo PET/CT | Ex Vivo PET/CT | Measure of |
|---|---|---|---|
| CTa,b | >7 mm3 | na | Tumor volume |
| 18F-FDGa | <1.5c | >3d | Glucose metabolism |
| 18F-Nifenea | 1.8-2.0c | >4d | α4β2 nAChR levels |
| 18F-FAHA | >2e | >6f | HDAC activity |
Animals were scanned 8-10 months post-NNK treatment.
a
Data taken from [8] Galitovskiy et al., 2013;
b
In vivo measures of tumor volume in NNK-treated animals (n=3, data are mean ± SD, p <0.05 for the three age groups);
c
Ratio of tumor/nontumor in NNK-treated animals in vivo;
d
Ratio of tumor/nontumor of ex vivo lung post-treatment measured using PET;
e
Ratio of tumor/nontumor 18F-FAHA in NNK-treated animals in vivo;
f
Ratio of tumor/nontumor of ex vivo lung 18F-FAHA post-treatment;
na: not available.