Figure 2.

Small-animal PET imaging of integrin α_vβ₆ expression in cancer. A: Representative transaxial PET images of [¹⁸F]FBA-A20FMDV2 and [¹⁸F]FDG in the same mouse with the positive (α_vβ₆-expressing DX3puroβ₆) tumors located near the left shoulder and the negative (control DX3puro) tumors near the right shoulder. Adapted with permission from the American Association for Cancer Research: ref. [50]. B: The photograph and PET image of a mouse bearing both BxPC-3 α_vβ₆-positive (T+) and α_vβ₆-negative 293 (T-) xenografts injected with ⁶⁴Cu-DOTA-S₀2. Adapted with permission from the American Association for Cancer Research: ref. [59].