Figure 3.

Small-animal SPECT imaging of integrin α_vβ₆ expression in cancer. (A) Small-animal SPECT (left) and SPECT/CT (right) images of mice bearing α_vβ₆-negative A375Ppuro (left shoulder) and α_vβ₆-positive A375Pβ₆ (right shoulder) tumors with ¹¹¹In-DTPA-A20FMDV2. Adapted with permission from ref. [71]. Copyright (2010) Pathological Society of Great Britain and Ireland. (B) Coronal SPECT/CT images of a mouse bearing α_vβ₆-positive HCC4006 xenograft (left) and a mouse bearing α_vβ₆-negative H838 xenograft (right) after injection of ^99mTc-SAAC-S₀2. Adapted with permission from ref. [74]. Copyright (2014) American Chemical Society. (C) Whole-body posterior and right lateral SPECT/CT images of nude mice with liver metastasis of α_vβ₆-positive BxPC-3 tumors after ^99mTc-HHK injection. (D) Mouse from (C) was sacrificed, and the liver metastasis was verified. This research was originally published in ref. [75]. Copyright (2014) the Society of Nuclear Medicine and Molecular Imaging, Inc.