Table 2.
Selected list of the molecular imaging probes targeted to integrin αvβ6
| Imaging modality | Probe | Targeting sequence | Disease model | Ref. |
|---|---|---|---|---|
| PET | [18F]FBA-A20FMDV2 | NAVPNLRGDLQVLAQKVART | Melanoma | [50] |
| [18F]FBA-PEG28-A20FMDV2 | Pancreatic cancer | [62] | ||
| [18F]FBA-(PEG28)2-A20FMDV2 | ||||
| 64Cu-PEG28-A20FMDV2 (using different chelators) | Melanoma | [67,68] | ||
| [18F]FBA-C6-ADIBON3-PEG7-A20FMDV2 | Melanoma | [64] | ||
| 64Cu-DOTA-R01 | GCILNMRTDLGTLLFRCRRDSDCPGACICRGNGYCG | Pancreatic and epidermoid cancer | [59] | |
| 64Cu-DOTA-S02 | GCRSLARTDLDHLRGRCSSDSDCLAECICLENGFCG | |||
| 18F-fluorobenzoate-R01 | GCILNMRTDLGTLLFRCRRDSDCPGACICRGNGYCG | Pancreatic cancer | [70] | |
| 18F-fluorobenzoate-S02 | GCRSLARTDLDHLRGRCSSDSDCLAECICLENGFCG | |||
| 64Cu-AcD10 | RGDLATLRQL | Non-small cell lung cancer | [69] | |
| SPECT | 125I/131I-HBP-1 | SPRGDLAVLGHKY | Head and neck squamous cell carcinoma | [58] |
| 111In-DTPA-A20FMDV2 | NAVPNLRGDLQV LAQKVART | Breast cancer and melanoma | [71] | |
| Pulmonary fibrosis | [78] | |||
| 123I-IFMDV2 | Pancreatic cancer | [72] | ||
| 111In-DTPA-Streptavidin-biotinylated-D25p | EPRGDLRTLAAREKENFNETLARL QEKGI | Melanoma | [73] | |
| 99mTc-SAAC-S02 | GCRSLARTDLDHLRGRCSSDSDCLAECICLENGFCG | Lung carcinoma | [74] | |
| 99mTc-HYNIC-HK | RGDLATLRQLAQEDGVVGVRK | Pancreatic cancer | [75] |