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. Author manuscript; available in PMC: 2014 Jun 29.
Published in final edited form as: Trends Cell Biol. 2011 Aug 6;21(10):569–576. doi: 10.1016/j.tcb.2011.06.008

Figure 2. High ROS phenotypes that affects aging and lifespan positively.

Figure 2

The C. elegans nuo-6 mutants produce more mitochondrial superoxide, yet display an increased lifespan that, furthermore, can be suppressed by the antioxidant NAC[43]. Mclk1+/− mice sustain high mitochondrial oxidative stress but live longer than their wild type siblings [48, 50]. High levels of oxidative damage have been observed in several tissues of very long-lived naked mole rats (NMRs) [56].