Table 1.

Differences between pediatric and adult membranous nephropathy (MN)

	Pediatric MN	Adult MN
Disease type/subtype:
Proportion of primary nephrotic syndrome cases that are MN	< 5% (children) 5–20% (adolescents)	15–30%
MN that is primary (“idiopathic”)	Minority	Majority
Proportion of primary MN that is PLA2R-associated	45% (more common in adolescents)	70–80%
Demographic and clinical features:
Male predominance	Variable	Yes
Full nephrotic syndrome	40–75%	75%
Microscopic hematuria	70–90% (can be macroscopic)	50%
Hypertension	< 10%	30%
Thromboembolic events	< 5%	10–20%
Spontaneous remission	Common	30%
Progressive renal impairment	< 25%	30–40%
Pathological features:
Mesangial deposits	Up to 50%	30%
Segmental distribution of deposits	Occasional	Very rare