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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Trends Cell Biol. 2014 Feb 23;24(7):426–434. doi: 10.1016/j.tcb.2014.01.005

Figure 3.

Figure 3

Synergistic function of histone methylation and ubiquitination in the recruitment of 53BP1. BBAP mediates monoubiquitination of H4 at lysine 91, which promotes SET8 recruitment, possibly through an associated partner that recognizes monoubiquitinated H4 (top). SET8 then promotes H4K20 methylation. RNF168 mediates monoubiquitination of H2A at lysine 15 near sites of DNA damage (middle). This monoubiquitination works in concert with H4K20 methylation to recruit 53BP1 via its respective tandem Tudor domains and the adjacent UDR motif (bottom).