A working model for the involvement of the ECM molecule versican influencing the behavior of cells during injury, remodeling, and inflammation in disease. The postulate follows that initial stimuli associated with disease initiation stimulates stromal cells or leukocytes to synthesize an ECM enriched in versican, which in turn influences these cells or other cells to proliferate, migrate, adhere, and remodel the ECM, promoting phenotypic changes associated with disease progression.