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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Biochim Biophys Acta. 2014 Jan 5;1840(8):2441–2451. doi: 10.1016/j.bbagen.2013.12.028

Figure 5.

Figure 5

ECM transitions required for cell proliferation and migration. In order for cells to change shape during division and migration, they must modify their pericellular environment by first degrading the existing ECM and replacing it with components that allow the cell to change shape. Two ECM molecules that are produced during these events and allow this to happen are hyaluronan (red) and versican (blue). These changes lead to expansion of the pericellular matrix and changes in the mechanical properties of the ECM that influence cell phenotype. [Permission will be obtained; Wight et al, 2011, Am J Physiol Gastrointest Liver Physiol.]