TABLE 4.
Vaccine Effectiveness According to Age
| Evaluation and Control Group | Source of Immunization Data | Cases | No. (%) Vaccinated | Controls | No. (%) Vaccinated | VE | 95% CI |
|---|---|---|---|---|---|---|---|
| a. 2 RV1 doses versus 0 doses | |||||||
| Controls: rotavirus-negative | |||||||
| Ages 8 mo–11 mo | Provider | 14 | 5 (36) | 61 | 45 (74) | 85 | 35 to 97 |
| Ages 12 mo–23 mo | Provider | 66 | 14 (21) | 68 | 46 (68) | 91 | 75 to 96 |
| Controls: IIS (matched)a | |||||||
| Ages 8 mo–11 mo | IIS | 14 | 4 (29) | 196 | 114 (58) | 70 | −4 to 91 |
| IIS, restricted | 14 | 4 (29) | 168 | 114 (68) | 89 | 48 to 98 | |
| Ages 12 mo–23 mo | IIS | 65 | 13 (20) | 967 | 462 (48) | 76 | 53 to 87 |
| IIS, restricted | 62 | 13 (21) | 781 | 452 (58) | 84 | 69 to 92 | |
| b. 3 RV5 doses versus 0 doses | |||||||
| Controls: rotavirus-negative | |||||||
| Ages 8 mo–11 mo | Provider | 10 | 1 (10) | 34 | 18 (53) | 94 | 37 to 99 |
| Ages 12 mo–23 mo | Provider | 55 | 3 (5) | 36 | 14 (39) | 90 | 56 to 98 |
| Controls: IIS (matched)a,b | |||||||
| Ages 8 mo–11 mo | IIS, Georgia only | 10 | 1 (10) | 111 | 45 (41) | 82 | (−50 to 98) |
| IIS, Georgia only, restricted | 10 | 1 (10) | 94 | 45 (48) | 88 | (0 to 99) | |
| Ages 12 mo–23 mo | IIS, Georgia only | 39 | 2 (5) | 535 | 198 (37) | 92 | 64 to 98 |
| IIS, Georgia only, restricted | 37 | 2 (5) | 405 | 185 (46) | 94 | 74 to 99 | |
“Restricted” indicates analysis was restricted to children that had at least 1 dose of DTaP, PCV or RV in IIS record.
a
Separate model was used for each age group.
b
Analysis performed only with Georgia IIS because IIS in Connecticut could not differentiate RV5 doses from doses with unknown manufacturer.