TABLE 5.
Vaccine Effectiveness among Children aged ≥ 8 months by Genotype
| Evaluation and Control Group | Source of Immunization Data | Cases | No. (%) Vaccinated | Controls | No. (%) Vaccinated | VE | 95% CI |
|---|---|---|---|---|---|---|---|
| a. 2 RV1 doses versus 0 doses | |||||||
| Controls: rotavirus-negative | |||||||
| G1P[8] cases | Provider | 43 | 9 (21) | 140 | 101 (72) | 89 | 70 to 96 |
| G2P[4] cases | Provider | 36 | 8 (22) | 90 | 64 (71) | 94a,b | 78 to 98 |
| Controls: IIS (matched) | |||||||
| G1P[8] cases | IIS | 43 | 7 (16) | 636 | 273 (43) | 78 | 48 to 91 |
| IIS, restricted | 42 | 7 (17) | 509 | 268 (53) | 88 | 68 to 95 | |
| G2P[4] cases | IIS | 33 | 7 (21) | 455 | 256 (56) | 81a | 52 to 92 |
| IIS, restricted | 30 | 7 (23) | 358 | 238 (66) | 88a | 68 to 95 | |
| b. 3 RV5 doses versus 0 doses | |||||||
| Controls: rotavirus-negative | |||||||
| G1P[8] cases | Provider | 37 | 3 (8) | 73 | 34 (47) | 95c | 74 to 99 |
| G2P[4] cases | Provider | 29 | 1 (3) | 50 | 24 (48) | 98a,d | 74 to 100 |
| Controls: IIS (matched)e | |||||||
| G1P[8] cases | IIS, Georgia only | 38 | 2 (5) | 493 | 174 (35) | 91 | 61 to 98 |
| IIS, Georgia only, restricted | 37 | 2 (5) | 390 | 172 (44) | 94 | 73 to 99 | |
“Restricted” indicates analysis was restricted to children that had at least 1 dose of DTaP, PCV or RV in IIS record.
a
Based only on data from season 2 because all G2P[4] cases occurred in season 2.
b
Model also included insurance status (without this adjustment, VE = 92% [95% CI 76 to 97]).
c
Model also included insurance status (without this adjustment, VE = 94% [95%CI 69 to 99]).
d
Model also included race (without this adjustment, VE = 96% [95% CI 59 to 99]).
e
Analysis performed only with Georgia IIS because IIS in Connecticut could not differentiate RV5 doses from doses with unknown manufacturer. Analysis for G2P[4] cases not performed because of insufficient cases from Georgia alone.