TABLE 3.
Multivariable Model for the Association Between Antianaerobic Antibiotic Exposure and IBD Developmenta
| Variable | N | Developed IBD | Unadjusted HR (95% CI) | aHR (95% CI) |
|---|---|---|---|---|
| Antianaerobic antibioticsb | ||||
| Exposed | 618 663 | 436 | 6.00 (1.93–18.66) | 5.51 (1.66–18.28) |
| Unexposed | 453 763 | 312 | 1 (Reference) | |
| Family history of IBD | ||||
| Present | 356 | 12 | 42.05 (23.77–74.39) | 35.57 (19.67–64.31) |
| Absent | 1 072 070 | 736 | 1 (Reference) | |
| Gender | ||||
| Female | 516 904 | 305 | 0.76 (0.66–0.88) | 0.75 (0.64–0.87) |
| Male | 555 522 | 443 | 1 (Reference) | |
| Chronic granulomatous disease | ||||
| Present | 19 | 4 | 286.62 (107.29–765.74) | 243.93 (76.89–773.78) |
| Absent | 1 072 407 | 744 | 1 (Reference) | |
| Primary sclerosing cholangitis | ||||
| Present | 17 | 9 | 734.29 (380.36–1417.57) | 852.12 (328.43–2210.88) |
| Absent | 1 072 409 | 739 | 1 (Reference) | |
| Socioeconomic deprivationc | ||||
| Most deprived | 866 909 | 76 | 0.76 (0.60–0.96) | 0.75 (0.57–0.97) |
| All others | 140 769 | 645 | 1 (Reference) | |
a
Excludes exposures during the median latency period (3.9 months) before cohort censorship for all subjects.
b
Represents the increased hazard of developing IBD with exposure before 1 year of age; hazard decreased with increasing age.
c
Subject numbers do not sum to overall cohort totals due to missing values.