Table 2. The top 20 potential disease related miRNAs predicted by RLSMDA in the global ranking and the confirmation for their associations by various databases are listed here. Fifteen of top 20 disease-miRNA associations have been confirmed.

Ranking	Diseases	miRNAs	Evidence
1	Colonic Neoplasms	hsa-mir-222	dbDEMC
2	Stomach Neoplasms	hsa-mir-451	miR2Disease
3	Ovarian Neoplasms	hsa-mir-15a
4	Colorectal Neoplasms	hsa-mir-19a	HMDD,miR2Disease
5	Muscular Disorders, Atrophic	hsa-mir-206
6	Colonic Neoplasms	hsa-mir-203	dbDEMC,miR2Disease
7	Stomach Neoplasms	hsa-mir-19b
8	Breast Neoplasms	hsa-let-7e	HMDD,dbDEMC
9	Colonic Neoplasms	hsa-mir-92b
10	Carcinoma, Hepatocellular	hsa-mir-155	HMDD,dbDEMC,miR2Disease
11	Colorectal Neoplasms	hsa-mir-125b	HMDD
12	Breast Neoplasms	hsa-let-7b	HMDD,dbDEMC
13	Adenocarcinoma	hsa-mir-200b	HMDD
14	Colonic Neoplasms	hsa-mir-183	dbDEMC,miR2Disease
15	Breast Neoplasms	hsa-mir-92a	HMDD
16	Ovarian Neoplasms	hsa-mir-143	miR2Disease
17	Breast Neoplasms	hsa-mir-223	HMDD,dbDEMC
18	Neoplasms	hsa-mir-15a	HMDD
19	Breast Neoplasms	hsa-mir-16	HMDD,dbDEMC
20	Stomach Neoplasms	hsa-mir-92a