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The structure of IL-1β, IL-1R2 and IL-1RAP complex (PDB Code_Chains: 3o4o_ABC). Atoms of interface residues are represented with balls. There are many common residues on IL-1β that binds to IL-1R1 and IL-1R2. Purple residues (Gln48 and Glu111) are computational hot spots and are specific to IL-1R2 and IL1RAP binding, respectively.
