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TNFR1 and TNFR2 bind to the same site on TNF-α, thus they are mutually exclusive. The structure of the TNF-α and TNFR2 complex is available in the PDB (PDB Code_Chains: 1alq_AR), however, we modeled the TNF-α and TNFR1 interaction by PRISM [41]. Atoms of interface residues are represented with balls. Solid lines and rectangles indicate the position of interfaces on TNF-α. Since the rectangles overlap almost completely, these two interactions cannot co-exist.
