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. 2014 Mar 25;6(2):663–683. doi: 10.3390/cancers6020663

Figure 9.

Figure 9

The structure of the IL-10, IL-10RA and IL-10RB complex, obtained by superimposition of IL10-IL10RA and IL10-IL10RB complexes. The structure of the IL10-IL10RA is available in the PDB (PDB Code_Chains: 1y6k_LR) but interaction of IL-10 (PDB Code_Chain: 2ilk_A) with IL-10RB (PDB Code_Chain: 3lqm_A) was modeled by PRISM [41] in our previous study [87]. IL-10 needs to bind to both IL-10RA and IL-10RB simultaneously to propagate the signal downstream. The yellow region on IL-10RB below, would be gone in E41* mutant form of IL-10RB and this mutation abolishes the interaction of IL10-IL10RB since the majority of the interface would be missing.