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STAT3 is a transcription factor that can be activated by phosphorylation on Tyr705 by Jaks and other kinases. STAT3 then regulates the expression of genes controlling processes including proliferation, survival, invasion, and angiogenesis. STAT3 can also be phosphorylated on Ser727. This is important for its effects on mitochondrial function. STAT3 may also have effects at other cellular sites, including microtubules and focal adhesions.
