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. 2014 Apr 23;6(2):958–968. doi: 10.3390/cancers6020958

Figure 2.

Figure 2

STAT5 can modulate the effects of STAT3 in breast cancer. Breast cancers can be characterized by the constitutive activation of STAT3, STAT5, or both STATs concurrently. When STAT5 is activated in conjunction with STAT3, STAT5 plays a dominant role in binding to a subset of genomic STAT binding sites and altering STAT3-dependent gene expression. The co-activation of STAT5 with STAT3 is associated with a more favorable cancer phenotype and prognosis than tumors in which STAT3 is activated alone.