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Effects of AZD6244 and/or BEZ235 on the activities of caspase-3, 8 and 9 in NCI-1993, NCI-1975 and NCI-H460 xenograft models. All three gefitinib-resistant tumor xenograft models were treated with the AZD6244 and/or BEZ235 for 2 h on Day 21 of the efficacy study, tumor tissues in each group were resected and measured by caspase colorimetric protease kits. N = 10.
