Table 1.
Main effects of five SNPs previously associated with glioma, among Caucasians from five US studies (adjusted for age at diagnosis, study, and gender)
| SNP | Chromosome | Gene | Genotype | Controls | Glioma | OR (95 % CI) | p value |
|---|---|---|---|---|---|---|---|
| rs2736100 | 5 | TERT | TT | 789 (25.62) | 164 (20.25) | 1 (ref) | . |
| GT | 1511 (49.06) | 402 (49.63) | 1.28 (1.00–1.56) | 0.0502 | |||
| GG | 780 (25.32) | 244 (30.12) | 1.40 (1.10–1.80) | 0.0059 | |||
| GT + GG | 2291 (74.38) | 646 (79.75) | 1.30 (1.06–1.61) | 0.0126 | |||
| p trend | 0.0064 | ||||||
| rs4295627 | 8 | CCDC26 | TT | 2025 (65.68) | 483 (59.63) | 1 (ref) | . |
| GT | 935 (30.33) | 284 (35.06) | 1.32 (1.10–1.59) | 0.003 | |||
| GG | 123 (4.00) | 43 (5.31) | 1.76 (1.16–2.68) | 0.008 | |||
| GT + GG | 1058 (34.32) | 327 (40.37) | 1.37 (1.15–1.64) | 0.0005 | |||
| p trend | 0.0002 | ||||||
| rs4977756 | 9 | CDKN2A/B | AA | 1112 (36.09) | 248 (30.62) | 1 (ref) | . |
| AG | 1460 (47.39) | 383 (47.28) | 1.18 (0.97–1.44) | 0.09 | |||
| GG | 509 (16.52) | 179 (22.10) | 1.62 (1.27–2.07) | 0.0001 | |||
| AG + GG | 1969 (63.91) | 562 (69.38) | 1.29 (1.08–1.56) | 0.006 | |||
| p trend | 0.0002 | ||||||
| rs498872 | 11 | PHLDB1 | CC | 1427 (46.30) | 363 (44.93) | 1 (ref) | . |
| CT | 1341 (43.51) | 359 (44.43) | 1.07 (0.89–1.28) | 0.476 | |||
| TT | 314 (10.18) | 86 (10.64) | 1.09 (0.81–1.46) | 0.585 | |||
| CT + TT | 1655 (53.70) | 445 (55.07) | 1.07 (0.90–1.27) | 0.433 | |||
| p trend | 0.45 | ||||||
| rs6010620 | 20 | RTEL1 | AA | 148 (4.80) | 26 (3.21) | 1 (ref) | . |
| AG | 1014 (32.89) | 245 (30.25) | 1.48 (0.92–2.37) | 0.107 | |||
| GG | 1921 (62.31) | 539 (66.54) | 1.88 (1.18–2.98) | 0.007 | |||
| AG + AA | 2935 (95.20) | 784 (96.79) | 1.73 (1.09–2.74) | 0.019 | |||
| p trend | 0.0006 |