Table 3.

Stratified analysis of allergy and autoimmune factors by SNP for glioma risk among Caucasians in five US studies, adjusted for age, gender, and study

	rs2736100 (TERT)		rs4295627 (CCDC26)		rs4977756 (CDKN2A-CDKN2B)		rs6010620 (RTEL1)		rs498872 (PHLDB1)
	TT OR (95 % CI)	GT/GG OR (95 % CI)	TT OR (95 % CI)	GT/GG OR (95 % CI)	AA OR (95 % CI)	AG/GG OR (95 % CI)	AA OR (95 % CI)	AG/GG OR (95 % CI)	CC OR (95 % CI)	CT/TT OR (95 % CI)
Allergy
Asthma
No	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
Yes	0.51 (0.25–1.05)	0.60 (0.41–0.87)	0.67 (0.45–1.01)	0.48 (0.26–0.88)	0.61 (0.33–1.11)	0.56 (0.37–0.83)	0.26 (0.04–1.68)	0.59 (0.42–0.83)	0.63 (0.39–1.01)	0.54 (0.34–0.87)
	p interaction = 0.71		p interaction = 0.51		p interaction = 0.68		p interaction = 0.61		p interaction = 0.92
Any allergy
No	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
Yes	0.66 (0.39–1.12)	0.72 (0.55–0.96)	0.80 (0.59–1.09)	0.60 (0.39–0.91)	0.79 (0.51–1.21)	0.66 (0.49–0.90)	0.36 (0.08–1.72)	0.73 (0.57–0.94)	0.64 (0.44–0.93)	0.78 (0.56–1.09)
	p interaction = 0.86		p interaction = 0.61		p interaction = 0.42		p interaction = 0.31		p interaction = 0.24
Autoimmune
Diabetes
No	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
Yes	0.33 (0.11–1.01)	0.56 (0.34–1.01)	0.46 (0.26–0.82)	0.53 (0.27–1.07)	0.43 (0.18–1.00)	0.55 (0.33–0.93)	0 –	0.52 (0.33–0.81)	0.34 (0.18–0.67)	0.72 (0.40–1.31)
	p interaction = 0.42		p interaction = 0.68		p interaction = 0.60		p interaction = 0.97		p interaction = 0.16
Any Autoimmune
No	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
Yes	0.62 (0.31–1.25)	0.66 (0.46–0.96)	0.72 (0.48–1.06)	0.52 (0.29–0.91)	0.42 (0.22–0.81)	0.77 (0.53–1.11)	0.15 (0.01–1.67)	0.68 (0.49–0.95)	0.69 (0.44–1.11)	0.59 (0.37–0.92)
	p interaction = 0.86		p interaction = 0.44		p interaction = 0.14		p interaction = 0.24		p interaction = 0.50