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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: In Vivo. 2014 Mar-Apr;28(2):147–171.

Table I.

Comparison of baseline levels of gene transcripts between C57BL/6NHsd and C3H/HeNHsd whole lungs.

Mouse Strain NFKB Nrf2 SP1 AP1 vWF
C57BL/6NHsd 38.55±1.27
(n=4)		 25.60±0.63
(n=4)		 9.93±0.87
(n=4)		 15.70±0.88
(n=4)		 39.53±1.06
(n=4)
C3H/HeNHsd 39.80±2.01
(n=4)		 24.68±1.29
(n=4)		 11.63±1.31
(n=4)		 17.93±1.78
(n=4)		 36.85±1.61
(n=4)
p 0.3337 0.2451 0.0738 0.0661 0.0320
Mouse Strain VEGFa FGF1 CTGF IL6 SOD2
C57BL/6NHsd 17.30±0.84
(n=4)		 20.67±1.23
(n=4)		 11.35±0.88
(n=4)		 20.13±0.99
(n=4)		 38.78±1.12
(n=4)
C3H/HeNHsd 15.48±1.04
(n=4)		 19.33±0.69
(n=4)		 14.33±1.22
(n=4)		 21.20±1.68
(n=4)		 35.95±2.03
(n=4)
p 0.0342 0.1038 0.0076 0.3129 0.0511
Mouse Strain TGFb Lysl Ox IGFbp7 TNFa Col1a
C57BL/6NHsd 21.20±0.95
(n=4)		 26.05±0.79
(n=4)		 11.38±0.59
(n=4)		 23.23±0.67
(n=4)		 16.28±0.73
(n=4)
C3H/HeNHsd 19.03±0.92
(n=4)		 27.28±0.61
(n=4)		 12.33±0.66
(n=4)		 21.05±0.85
(n=4)		 14.93±0.51
(n=4)
p 0.0166 0.0486 0.0747 0.0071 0.0226
Mouse Strain TLR1 TLR2 TLR4 TLR5 TLR6
C57BL/6NHsd 15.35±0.48
(n=4)		 20.60±0.74
(n=4)		 23.10±0.79
(n=4)		 11.45±1.05
(n=4)		 15.00±0.55
(n=4)
C3H/HeNHsd 13.53±1.24
(n=4)		 20.53±1.30
(n=4)		 20.63±1.58
(n=4)		 10.18±0.77
(n=4)		 15.93±0.62
(n=4)
p 0.0337 0.9237 0.0307 0.0977 0.0664
Mouse Strain TLR7 BRD1 BRD2 BRD3 BRD4
C57BL/6NHsd 19.15±0.62
(n=4)		 11.45±0.88
(n=4)		 15.48±1.02
(n=4)		 9.30±0.74
(n=4)		 10.45±0.52
(n=4)
C3H/HeNHsd 21.48±1.11
(n=4)		 10.30±0.76
(n=4)		 13.35±0.67
(n=4)		 6.30±1.01
(n=4)		 9.80±0.50
(n=4)
p 0.0108 0.0957 0.0132 0.0030 0.1205

Transcript levels were standardized to glycerol phosphate dehydrogenase (GPDH) levels, which were the same in the lungs of both strains. Data is summarized as mean ± standard deviation for each group. For each of the 25 gene transcript levels, C57BL/6NHsd and C3H/HeNHsd were compared with the two-sided two-sample t-test. P-values less than 0.05 were significant. As this was an exploratory study, p-values were not adjusted for multiple comparisons.

Significant differences are shown in red.