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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: In Vivo. 2014 Mar-Apr;28(2):147–171.

Table III.

Gene expression in Lungs of 20 Gy Irradiated C57BL/6NHsd mice

day vWF TGFb TNFa FGF1 VEGFa
0 −0.33±39.07
(n=6)		 −25.60±26.54
(n=5)		 −14.00±45.74
(n=6)		 −28.17±41.02
(n=6)		 −5.80±43.60
(n=5)
2 656.60±284.71
(n=5)		 35.60±59.34
(n=5)		 293.46±121.95
(n=5)		 329.71±218.05
(n=7)		 211.60±127.47
(n=5)
p=0.0003 p=0.0684 p=0.0003 p=0.0023 p=0.0069
14 2881.17±2323.88
(n=6)		 243.00±187.15
(n=4)		 139.83±26.14
(n=4)		 1205.20±791.34
(n=5)		 1009.57±1216.80
(n=7)
p=0.0125 p=0.0145 p=0.0003 p=0.0039 p=0.0958
28 2366.29±2279.84
(n=7)		 37.88±100.57
(n=8)		 61.00±48.97
(n=5)		 61.34±161.85
(n=5)		 341.25±169.37
(n=4)
p=0.0282 p=0.2007 p=0.0276 p=0.2200 p=0.0029
60 519.67±55.43
(n=3)		 −90.78±3.90
(n=5)		 28.20±17.30
(n=4)		 73.33±83.58
(n=3)		 91.00±28.90
(n=4)
p<0.0001 p=0.0006 p=0.1209 p=0.0388 p=0.0067
100 449.43±86.67
(n=7)		 −73.60±12.60
(n=5)		 −23.80±34.52
(n=5)		 44.60±24.10
(n=5)		 179.33±82.98
(n=6)
p<0.0001 p=0.0065 p=0.7031 p=0.0069 p=0.0015
125 387.20±198.74
(n=5)		 10.40±3.51
(n=5)		 27.90±10.98
(n=5)		 84.60±15.57
(n=5)		 167.60±133.55
(n=5)
p=0.0011 p=0.0169 p=0.0785 p=0.0003 p=0.0247
150 378.67±30.66
(n=3)		 104.20±81.28
(n=5)		 152.33±4.04
(n=3)		 196.33±52.17
(n=3)		 199.33±34.82
(n=3)
p<0.0001 p=0.0094 p=0.0005 p=0.0002 p=0.0005
200 584.50±26.84
(n=4)		 259.75±53.65
(n=4)		 157.83±58.40
(n=6)		 447.00±72.17
(n=4)		 207.50±25.15
(n=4)
p<0.0001 p<0.0001 p=0.0002 p<0.0001 p=0.0001
(2)
day CTGF SOD2 IL6 NFkb NFE212
0 3.50±28.01
(n=6)		 −41.50±20.15
(n=6)		 −1.75±29.55
(n=4)		 62.40±27.13
(n=5)		 −25.83±15.41
(n=6)
2 1724.40±1855.84
(n=5)		 126.67±137.59
(n=6)		 150.50±37.56
(n=4)		 176.33±40.06
(n=6)		 78.83±95.51
(n=6)
p=0.0473 p=0.0142 p=0.0007 p=0.0004 p=0.0243
14 3104.67±1209.43
(n=3)		 313.50±333.58
(n=6)		 −9.87±38.81
(n=3)		 101.83±40.79
(n=6)		 2.33±10.80
(n=6)
p=0.0003 p=0.0264 p=0.7643 p=0.0988 p=0.0043
28 421.00±451.75
(n=5)		 172.84±292.60
(n=8)		 18.70±5.05
(n=4)		 96.67±31.03
(n=6)		 −25.00±22.66
(n=6)
p=0.0483 p=0.1016 p=0.2214 p=0.0860 p=0.9421
60 373.67±211.11
(n=3)		 −15.83±43.23
(n=6)		 −9.00±38.97
(n=4)		 34.45±13.00
(n=6)		 −64.55±21.04
(n=6)
p=0.0027 p=0.2168 p=0.7768 p=0.0511 p=0.0046
100 248.00±68.71
(n=4)		 −21.00±10.88
(n=7)		 88.20±110.49
(n=5)		 40.86±24.42
(n=7)		 −67.14±17.58
(n=7)
p<0.0001 p=0.0395 p=0.1618 p=0.1803 p=0.0010
125 489.00±166.78
(n=5)		 77.80±38.28
(n=5)		 302.40±199.68
(n=5)		 117.33±4.73
(n=3)		 26.00±6.24
(n=3)
p=0.0001 p=0.0001 p=0.0205 p=0.0150 p=0.0010
150 3944.67±478.16
(n=3)		 148.33±55.90
(n=3)		 638.33±62.07
(n=3)		 210.00±1.00
(n=3)		 59.67±11.50
(n=3)
p<0.0001 p=0.0001 p<0.0001 p=0.0001 p=0.0001
200 3416.25±135.91
(n=4)		 90.00±11.40
(n=4)		 379.75±25.91
(n=4)		 170.25±11.76
(n=4)		 79.25±7.93
(n=4)
p<0.0001 p<0.0001 p<0.0001 p=0.0002 p<0.0001
(3)
day Sp1 Ap1 Lysl Ox IGFbp7 TLR4
0 −12.00±22.93
(n=7)		 −18.00±15.06
(n=6)		 −5.40±13.70
(n=5)		 3.00±5.00
(n=3)		 −23.00±25.65
(n=4)
2 111.50±26.88
(n=6)		 77.83±20.43
(n=6)		 62.00±8.89
(n=3)		 −76.33±6.03
(n=3)		 −59.00±12.91
(n=4)
p<0.0001 p<0.0001 p=0.0003 p=0.0001 p=0.0461
14 −20.08±15.13
(n=6)		 −14.86±35.14
(n=7)		 39.67±4.51
(n=3)		 −54.33±11.15
(n=3)		 −45.75±19.12
(n=4)
p=0.4778 p=0.8430 p=0.0017 p=0.0012 p=0.2048
28 −28.17±9.87
(n=6)		 −31.00±15.85
(n=7)		 −25.67±11.68
(n=3)		 13.70±6.02
(n=3)		 −48.67±9.61
(n=3)
p=0.1386 p=0.1598 p=0.0778 p=0.0770 p=0.1667
60 −59.82±18.71
(n=6)		 −79.15±10.25
(n=6)		 −39.33±2.08
(n=3)		 91.67±3.06
(n=3)		 −49.50±20.44
(n=4)
p=0.0019 p<0.0001 p=0.0062 p<0.0001 p=0.1572
100 −67.14±24.67
(n=7)		 −90.54±6.92
(n=7)		 −13.67±6.03
(n=3)		 101.00±7.55
(n=3)		 44.40±15.44
(n=5)
p=0.0010 p<0.0001 p=0.3713 p<0.0001 p=0.0017
125 20.80±11.14
(n=5)		 6.60±2.30
(n=5)		 32.67±3.51
(n=3)		 199.67±18.88
(n=3)		 −48.40±12.82
(n=5)
p=0.0150 p=0.0059 p=0.0038 p=0.0001 p=0.0918
150 32.00±8.89
(n=3)		 24.00±11.14
(n=3)		 98.33±10.07
(n=3)		 893.67±167.82
(n=3)		 96.80±5.26
(n=5)
p=0.0140 p=0.0039 p<0.0001 p=0.0008 p<0.0001
200 103.00±14.31
(n=4)		 76.25±17.80
(n=4)		 114.33±25.70
(n=3)		 1029.33±70.12
(n=3)		 176.17±40.26
(n=6)
p<0.0001 p<0.0001 p=0.0001 p<0.0001 p<0.0001
(4)
day TLR1 TLR2 TLR5 TLR6 TLR7
0 2.33±4.93
(n=3)		 2.80±2.55
(n=3)		 5.20±9.00
(n=3)		 6.00±5.29
(n=3)		 8.30±4.03
(n=3)
2 384.00±58.41
(n=3)		 −14.00±5.00
(n=3)		 148.67±25.11
(n=3)		 407.33±17.79
(n=3)		 432.33±40.92
(n=3)
p=0.0004 p=0.0066 p=0.0007 p<0.0001 p=0.0001
14 82.00±10.82
(n=3)		 −53.33±12.01
(n=3)		 161.67±13.20
(n=3)		 511.67±9.71
(n=3)		 166.00±30.27
(n=3)
p=0.0003 p=0.0014 p=0.0001 p<0.0001 p=0.0009
28 121.00±11.53
(n=3)		 5.33±4.04
(n=3)		 120.67±10.02
(n=3)		 2.93±3.58
(n=3)		 122.00±12.00
(n=3)
p=0.0001 p=0.4106 p=0.0001 p=0.4525 p=0.0001
60 203.67±8.08
(n=3)		 −42.33±6.81
(n=3)		 74.67±11.68
(n=3)		 511.00±11.53
(n=3)		 4.67±6.11
(n=3)
p<0.0001 p=0.0004 p=0.0012 p<0.0001 p=0.4385
100 194.33±13.32
(n=3)		 −51.00±4.58
(n=3)		 33.33±10.50
(n=3)		 12.33±4.51
(n=3)		 208.00±15.13
(n=3)
p<0.0001 p=0.0001 p=0.0244 p=0.1897 p<0.0001
125 337.67±32.81
(n=3)		 225.00±11.00
(n=3)		 124.00±21.93
(n=3)		 9.53±5.28
(n=3)		 257.67±18.50
(n=3)
p=0.0001 p<0.0001 p=0.0010 p=0.4591 p<0.0001
150 134.00±14.42
(n=3)		 209.33±10.69
(n=3)		 265.00±24.58
(n=3)		 206.33±9.71
(n=3)		 942.33±52.20
(n=3)
p=0.0001 p<0.0001 p=0.0001 p<0.0001 p<0.0001
200 91.67±6.66
(n=3)		 217.67±10.02
(n=3)		 294.00±37.51
(n=3)		 213.67±22.68
(n=3)		 801.33±22.05
(n=3)
p<0.0001 p<0.0001 p=0.0002 p=0.0001 p<0.0001
(5)
day Col1A BRD1 BRD2 BRD3 BRD4
0 6.50±4.19
(n=4)		 8.80±3.70
(n=5)		 6.28±3.21
(n=5)		 7.00±3.39
(n=5)		 7.20±3.35
(n=5)
2 349.00±233.42
(n=3)		 −37.82±6.11
(n=5)		 34.98±6.66
(n=5)		 −31.60±7.13
(n=5)		 −31.80±8.47
(n=5)
p=0.0289 p<0.0001 p<0.0001 p<0.0001 p<0.0001
14 −
(n=0)		 −26.66±4.63
(n=5)		 61.80±13.52
(n=5)		 −11.60±6.19
(n=5)		 −30.78±10.89
(n=5)
p<0.0001 p<0.0001 p=0.0004 p=0.0001
28 225.50±85.56
(n=2)		 19.40±6.80
(n=5)		 69.92±19.41
(n=5)		 13.80±7.19
(n=5)		 −2.44±12.92
(n=5)
p=0.0042 p=0.0156 p=0.0001 p=0.0922 p=0.1449
60 128.50±45.21
(n=4)		 57.08±9.94
(n=5)		 112.80±9.12
(n=5)		 54.20±12.52
(n=5)		 37.40±12.01
(n=5)
p=0.0017 p<0.0001 p<0.0001 p<0.0001 p=0.0006
100 3.58±13.89
(n=4)		 151.60±5.86
(n=5)		 64.00±10.22
(n=5)		 131.20±12.83
(n=5)		 123.20±7.66
(n=5)
p=0.7007 p<0.0001 p<0.0001 p<0.0001 p<0.0001
125 30.50±30.16
(n=4)		 70.60±9.61
(n=5)		 59.80±6.30
(n=5)		 33.00±6.20
(n=5)		 47.02±8.16
(n=5)
p=0.1660 p<0.0001 p<0.0001 p<0.0001 p<0.0001
150 58.50±69.36
(n=4)		 −55.82±8.51
(n=5)		 73.40±6.69
(n=5)		 −34.20±11.54
(n=5)		 −25.80±7.36
(n=5)
p=0.1851 p<0.0001 p<0.0001 p=0.0001 p<0.0001
200 299.33±34.27
(n=3)		 −61.60±3.05
(n=5)		 −4.80±22.69
(n=5)		 −63.20±5.72
(n=5)		 −52.20±9.26
(n=5)
p<0.0001 p<0.0001 p=0.3111 p<0.0001 p<0.0001

Data summary using mean ± SD and group comparisons, where p is the p-value for the comparison of gene expression in lungs of C57BL/6NHsd mice between each day and day 0 for the corresponding gene, using the two-sided two sample t-test.