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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: In Vivo. 2014 Mar-Apr;28(2):147–171.

Table IV.

Gene expression in lungs of 20 Gy thoracic irradiated C3H/HeNHsd mice.

day vWF TGFb TNFa FGF1 VEGFa
0 2.13±11.08
(n=4)		 −1.25±16.34
(n=4)		 −0.75±9.91
(n=4)		 −1.25±10.12
(n=4)		 −0.50±8.76
(n=4)
p2=0.9071 p2=0.1544 p2=0.5909 p2=0.2421 p2=0.8200
2 −0.45±9.08
(n=4)		 22.32±7.56
(n=4)		 64.73±10.73
(n=4)		 1.25±3.34
(n=4)		 100.68±13.78
(n=4)
p1=0.7315 p1=0.0396 p1=0.0001 p1=0.6555 p1<0.0001
p2=0.0026 p2=0.6742 p2=0.0078 p2=0.0164 p2=0.1313
14 5.96±2.04
(n=4)		 116.75±12.43
(n=4)		 50.15±7.44
(n=4)		 4.13±1.47
(n=4)		 131.28±6.15
(n=4)
p1=0.5214 p1<0.0001 p1=0.0002 p1=0.3336 p1<0.0001
p2=0.0416 p2=0.2269 p2=0.0006 p2=0.0201 p2=0.1920
28 40.00±8.69
(n=4)		 87.23±6.24
(n=4)		 52.83±8.90
(n=4)		 −17.33±5.07
(n=4)		 144.98±20.40
(n=4)
p1=0.0017 p1=0.0001 p1=0.0002 p1=0.0295 p1<0.0001
p2=0.0773 p2=0.3611 p2=0.7546 p2=0.3699 p2=0.0610
60 52.95±12.79
(n=4)		 73.10±11.46
(n=4)		 4.75±13.84
(n=4)		 −40.10±6.69
(n=4)		 120.50±12.40
(n=4)
p1=0.0010 p1=0.0003 p1=0.5421 p1=0.0007 p1<0.0001
p2<0.0001 p2<0.0001 p2=0.0786 p2=0.0382 p2=0.1097
100 65.25±6.24
(n=4)		 47.63±14.19
(n=4)		 19.43±8.95
(n=4)		 −15.75±3.77
(n=4)		 141.00±19.41
(n=4)
p1=0.0001 p1=0.0040 p1=0.0233 p1=0.0363 p1<0.0001
p2<0.0001 p2<0.0001 p2=0.0468 p2=0.0018 p2=0.3990
125 63.50±5.20
(n=4)		 41.85±10.25
(n=4)		 44.50±9.57
(n=4)		 3.25±11.24
(n=4)		 157.50±22.49
(n=4)
p1=0.0001 p1=0.0042 p1=0.0006 p1=0.5735 p1<0.0001
p2=0.0148 p2=0.0003 p2=0.0489 p2=0.0001 p2=0.8868
150 94.50±15.93
(n=4)		 27.25±13.57
(n=4)		 126.33±11.73
(n=4)		 5.43±6.51
(n=4)		 189.25±30.82
(n=4)
p1=0.0001 p1=0.0364 p1<0.0001 p1=0.3096 p1<0.0001
p2<0.0001 p2=0.1071 p2=0.0154 p2=0.0007 p2=0.7012
200 88.03±5.90
(n=4)		 21.80±5.57
(n=4)		 124.00±15.12
(n=4)		 13.95±7.27
(n=4)		 193.28±10.99
(n=4)
p1<0.0001 p1=0.0370 p1<0.0001 p1=0.0505 p1<0.0001
p2<0.0001 p2=0.0001 p2=0.2980 p2<0.0001 p2=0.3398
(2)
day CTGF SOD2 IL6 NFkb NFE212
0 −4.00±17.11
(n=4)		 5.25±14.08
(n=4)		 5.55±8.13
(n=4)		 3.50±10.21
(n=4)		 1.22±11.25
(n=4)
p2=0.6479 p2=0.0040 p2=0.6506 p2=0.0047 p2=0.0172
2 69.75±8.15
(n=4)		 −11.03±1.07
(n=4)		 367.00±55.98
(n=4)		 152.88±16.54
(n=4)		 −12.13±6.02
(n=4)
p1=0.0002 p1=0.0607 p1<0.0001 p1<0.0001 p1=0.0814
p2=0.1221 p2=0.0855 p2=0.0007 p2=0.3063 p2=0.0993
14 130.90±7.21
(n=4)		 −11.30±2.75
(n=4)		 216.75±47.06
(n=4)		 88.45±20.80
(n=4)		 165.85±6.99
(n=4)
p1<0.0001 p1=0.0605 p1=0.0001 p1=0.0003 p1<0.0001
p2=0.0038 p2=0.0928 p2=0.0011 p2=0.5664 p2<0.0001
28 218.75±49.39
(n=4)		 63.05±6.82
(n=4)		 95.15±10.36
(n=4)		 38.63±6.44
(n=4)		 101.60±26.40
(n=4)
p1=0.0001 p1=0.0003 p1<0.0001 p1=0.0011 p1=0.0004
p2=0.4086 p2=0.4808 p2<0.0001 p2=0.0068 p2<0.0001
60 100.73±8.46
(n=4)		 53.85±8.36
(n=4)		 117.25±17.29
(n=4)		 61.28±7.93
(n=4)		 50.90±9.65
(n=4)
p1<0.0001 p1=0.0010 p1<0.0001 p1=0.0001 p1=0.0005
p2=0.0442 p2=0.0141 p2=0.0010 p2=0.0064 p2<0.0001
100 120.75±11.95
(n=4)		 34.95±8.08
(n=4)		 125.38±18.35
(n=4)		 23.90±8.26
(n=4)		 52.25±15.31
(n=4)
p1<0.0001 p1=0.0106 p1<0.0001 p1=0.0209 p1=0.0017
p2=0.0107 p2<0.0001 p2=0.5323 p2=0.2195 p2<0.0001
125 136.75±11.24
(n=4)		 49.00±15.25
(n=4)		 121.25±12.97
(n=4)		 19.80±7.30
(n=4)		 80.10±11.62
(n=4)
p1<0.0001 p1=0.0056 p1<0.0001 p1=0.0407 p1=0.0001
p2=0.0043 p2=0.2036 p2=0.1172 p2<0.0001 p2=0.0008
150 138.75±11.44
(n=4)		 219.75±27.10
(n=4)		 116.25±15.73
(n=4)		 13.13±5.34
(n=4)		 177.75±22.32
(n=4)
p1<0.0001 p1<0.0001 p1<0.0001 p1=0.1457 p1<0.0001
p2<0.0001 p2=0.0720 p2<0.0001 p2<0.0001 p2=0.0004
200 155.30±8.99
(n=4)		 170.75±24.06
(n=4)		 114.03±10.25
(n=4)		 20.13±7.62
(n=4)		 195.75±13.60
(n=4)
p1<0.0001 p1<0.0001 p1<0.0001 p1=0.0401 p1<0.0001
p2<0.0001 p2=0.0009 p2<0.0001 p2<0.0001 p2<0.0001
(3)
day Sp1 Ap1 Lysl Ox IGFbp7 TLR4
0 5.03±10.32
(n=4)		 −2.68±9.42
(n=4)		 3.00±19.11
(n=4)		 1.28±10.01
(n=4)		 2.55±9.04
(n=4)
p2=0.2002 p2=0.1105 p2=0.4660 p2=0.7981 p2=0.1093
2 17.00±5.16
(n=4)		 22.48±6.19
(n=4)		 243.45±53.97
(n=4)		 −23.43±6.17
(n=4)		 −17.75±6.03
(n=4)
p1=0.0832 p1=0.0043 p1=0.0002 p1=0.0057 p1=0.0097
p2=0.0001 p2=0.0009 p2=0.0024 p2=0.0001 p2=0.0012
14 104.25±19.62
(n=4)		 22.98±6.69
(n=4)		 197.00±13.52
(n=4)		 −12.30±6.23
(n=4)		 −16.10±4.75
(n=4)
p1=0.0001 p1=0.0044 p1<0.0001 p1=0.0609 p1=0.0107
p2<0.0001 p2=0.0667 p2<0.0001 p2=0.0013 p2=0.0237
28 93.90±6.71
(n=4)		 −49.28±6.51
(n=4)		 164.50±9.88
(n=4)		 −16.18±6.11
(n=4)		 −16.33±6.20
(n=4)
p1<0.0001 p1=0.0002 p1<0.0001 p1=0.0248 p1=0.0138
p2<0.0001 p2=0.0588 p2<0.0001 p2=0.0013 p2=0.0028
60 31.23±10.83
(n=4)		 −55.90±11.11
(n=4)		 124.23±13.38
(n=4)		 −15.50±6.65
(n=4)		 −26.75±9.00
(n=4)
p1=0.0128 p1=0.0003 p1<0.0001 p1=0.0315 p1=0.0037
p2<0.0001 p2=0.0093 p2<0.0001 p2<0.0001 p2=0.0877
100 15.03±7.23
(n=4)		 −31.50±9.18
(n=4)		 126.00±14.94
(n=4)		 −7.98±13.97
(n=4)		 10.20±4.24
(n=4)
p1=0.1635 p1=0.0047 p1=0.0001 p1=0.3231 p1=0.1764
p2=0.0001 p2<0.0001 p2<0.0001 p2=0.0001 p2=0.0038
125 68.03±7.55
(n=4)		 41.50±11.56
(n=4)		 107.75±24.74
(n=4)		 −9.00±10.42
(n=4)		 9.10±3.33
(n=4)
p1=0.0001 p1=0.0010 p1=0.0005 p1=0.2049 p1=0.2229
p2=0.0002 p2=0.0003 p2=0.0038 p2<0.0001 p2=0.0001
150 219.50±50.35
(n=4)		 169.50±19.54
(n=4)		 139.53±11.81
(n=4)		 13.33±6.40
(n=4)		 9.65±14.45
(n=4)
p1=0.0002 p1<0.0001 p1<0.0001 p1=0.0888 p1=0.4368
p2=0.0016 p2=0.0001 p2=0.0047 p2=0.0001 p2<0.0001
200 167.75±22.10
(n=4)		 145.25±11.03
(n=4)		 128.25±16.32
(n=4)		 9.73±2.58
(n=4)		 4.35±10.70
(n=4)
p1<0.0001 p1<0.0001 p1=0.0001 p1=0.1531 p1=0.8058
p2=0.0027 p2=0.0006 p2=0.4167 p2<0.0001 p2<0.0001
(4)
day TLR1 TLR2 TLR5 TLR6 TLR7
0 5.67±8.62
(n=3)		 3.33±13.58
(n=3)		 6.20±4.53
(n=3)		 −1.13±16.56
(n=3)		 8.00±10.82
(n=3)
p2=0.5923 p2=0.9499 p2=0.8718 p2=0.5165 p2=0.9663
2 299.67±30.11
(n=3)		 −17.67±7.02
(n=3)		 149.67±23.44
(n=3)		 357.67±19.01
(n=3)		 404.33±7.02
(n=3)
p1=0.0001 p1=0.0760 p1=0.0005 p1<0.0001 p1<0.0001
p2=0.0903 p2=0.5022 p2=0.9622 p2=0.0298 p2=0.3076
14 68.03±10.87
(n=3)		 −50.00±17.52
(n=3)		 160.67±13.80
(n=3)		 504.33±8.50
(n=3)		 158.00±29.51
(n=3)
p1=0.0015 p1=0.0141 p1=0.0001 p1<0.0001 p1=0.0012
p2=0.1898 p2=0.7993 p2=0.9321 p2=0.3809 p2=0.7595
28 116.67±26.35
(n=3)		 3.00±9.54
(n=3)		 122.00±18.68
(n=3)		 8.63±5.08
(n=3)		 116.33±11.02
(n=3)
p1=0.0023 p1=0.9739 p1=0.0005 p1=0.3841 p1=0.0003
p2=0.8070 p2=0.7163 p2=0.9185 p2=0.1873 p2=0.5793
60 192.33±22.74
(n=3)		 −35.33±10.97
(n=3)		 80.67±7.02
(n=3)		 484.00±23.26
(n=3)		 9.33±17.79
(n=3)
p1=0.0002 p1=0.0185 p1=0.0001 p1<0.0001 p1=0.9170
p2=0.4617 p2=0.4008 p2=0.4881 p2=0.1460 p2=0.6895
100 181.33±63.89
(n=3)		 −55.00±12.77
(n=3)		 26.33±8.33
(n=3)		 9.87±4.20
(n=3)		 191.67±7.64
(n=3)
p1=0.0092 p1=0.0056 p1=0.0212 p1=0.3273 p1<0.0001
p2=0.7475 p2=0.6364 p2=0.4169 p2=0.5263 p2=0.1705
125 326.33±17.50
(n=3)		 227.00±20.95
(n=3)		 122.00±13.00
(n=3)		 16.00±8.54
(n=3)		 242.67±22.05
(n=3)
p1<0.0001 p1=0.0001 p1=0.0001 p1=0.1865 p1=0.0001
p2=0.6255 p2=0.8907 p2=0.8985 p2=0.3273 p2=0.4178
150 140.33±36.35
(n=3)		 197.00±9.17
(n=3)		 285.33±17.16
(n=3)		 199.67±21.13
(n=3)		 902.00±23.30
(n=3)
p1=0.0034 p1<0.0001 p1<0.0001 p1=0.0002 p1<0.0001
p2=0.7930 p2=0.2039 p2=0.3052 p2=0.6455 p2=0.2888
200 97.73±13.21
(n=3)		 216.33±8.08
(n=3)		 280.00±12.29
(n=3)		 220.00±21.63
(n=3)		 791.00±24.00
(n=3)
p1=0.0005 p1<0.0001 p1<0.0001 p1=0.0001 p1<0.0001
p2=0.5166 p2=0.8663 p2=0.5722 p2=0.7440 p2=0.6121
(5)
day Col1A BRD1 BRD2 BRD3 BRD4
0 6.50±8.81
(n=4)		 1.50±12.71
(n=4)		 0.48±13.10
(n=4)		 0.73±16.21
(n=4)		 1.50±10.14
(n=4)
p2=1.0000 p2=0.2552 p2=0.3639 p2=0.4200 p2=0.2706
2 30.88±11.75
(n=4)		 55.03±6.41
(n=4)		 56.00±8.38
(n=4)		 62.61±9.30
(n=4)		 112.28±26.18
(n=4)
p1=0.0160 p1=0.0003 p1=0.0004 p1=0.0006 p1=0.0002
p2=0.0373 p2<0.0001 p2=0.0040 p2<0.0001 p2<0.0001
14 14.60±5.97
(n=4)		 72.53±10.22
(n=4)		 69.38±8.06
(n=4)		 113.68±6.81
(n=4)		 142.65±12.76
(n=4)
p1=0.1789 p1=0.0001 p1=0.0001 p1<0.0001 p1<0.0001
p2=. p2<0.0001 p2=0.3589 p2<0.0001 p2<0.0001
28 14.03±7.09
(n=4)		 64.25±5.84
(n=4)		 50.63±7.62
(n=4)		 56.98±7.20
(n=4)		 121.55±12.14
(n=4)
p1=0.2317 p1=0.0001 p1=0.0006 p1=0.0007 p1<0.0001
p2=0.0048 p2<0.0001 p2=0.1059 p2<0.0001 p2<0.0001
60 16.63±6.20
(n=4)		 60.23±11.46
(n=4)		 63.13±10.22
(n=4)		 61.93±10.80
(n=4)		 111.43±10.64
(n=4)
p1=0.1092 p1=0.0005 p1=0.0003 p1=0.0008 p1<0.0001
p2=0.0027 p2=0.6721 p2=0.0001 p2=0.3621 p2<0.0001
100 12.53±1.76
(n=4)		 62.80±15.01
(n=4)		 80.75±10.47
(n=4)		 89.75±16.60
(n=4)		 120.25±8.77
(n=4)
p1=0.2285 p1=0.0008 p1=0.0001 p1=0.0003 p1<0.0001
p2=0.2482 p2<0.0001 p2=0.0463 p2=0.0038 p2=0.6064
125 15.53±3.35
(n=4)		 87.25±15.06
(n=4)		 61.05±7.76
(n=4)		 97.23±12.03
(n=4)		 130.75±21.23
(n=4)
p1=0.1041 p1=0.0001 p1=0.0002 p1=0.0001 p1<0.0001
p2=0.3618 p2=0.0823 p2=0.7967 p2<0.0001 p2=0.0001
150 11.43±6.01
(n=4)		 72.18±9.19
(n=4)		 31.50±11.10
(n=4)		 52.50±16.01
(n=4)		 155.00±15.41
(n=4)
p1=0.3915 p1=0.0001 p1=0.0112 p1=0.0039 p1<0.0001
p2=0.2250 p2<0.0001 p2=0.0002 p2<0.0001 p2<0.0001
200 5.05±15.35
(n=4)		 81.25±11.03
(n=4)		 70.25±20.42
(n=4)		 90.53±8.77
(n=4)		 143.50±15.80
(n=4)
p1=0.8753 p1=0.0001 p1=0.0012 p1=0.0001 p1<0.0001
p2<0.0001 p2<0.0001 p2=0.0013 p2<0.0001 p2<0.0001

Data summary using mean±SD and group comparisons, where p1 is the p-value for the comparison of gene expression in lungs of C3H/HeNHsd mice between each day and day 0 for the corresponding gene, p2 is the p-value for the comparison between C57BL/6NHsd mice and C3H/HeNHsd mice at the corresponding day for the corresponding gene. All these p-values were calculated with the two-sided two sample t-test.