Table 2.
Effect of formulation variables on the permeation of nanoencapsulated Rh B (F1–F8) and FITC (F9–F12) across MN-treated full thickness porcine skin. Values are mean ± SD (n ⩾ 3).
| Dye | Formula code | Q48 (μg/cm2) | Steady state flux (μg/cm2/h) |
|---|---|---|---|
| Rh B | F1 | 0.50 ± 0.20 | 0.81 ± 0.28 |
| F2 | 2.02 ± 0.11 | 2.83 ± 0.19 | |
| F3 | 2.49 ± 0.08 | 3.55 ± 0.09 | |
| F4 | 2.07 ± 0.19 | 2.90 ± 0.27 | |
| F5 | 2.92 ± 1.32 | 3.98 ± 1.62 | |
| F6 | 5.40 ± 0.39 | 6.19 ± 0.77 | |
| F7 | 2.99 ± 0.26 | 4.29 ± 0.42 | |
| F8 | 1.78 ± 0.63 | 2.53 ± 0.87 | |
| FITC | F9 | 0.13 ± 0.04 | 0.17 ± 0.05 |
| F10 | 0.09 ± 0.01 | 0.12 ± 0.02 | |
| F11 | 0.06 ± 0.02 | 0.09 ± 0.03 | |
| F12 | 0.24 ± 0.08 | 0.35 ± 0.11 | |