Table 1.
In vivo antimalarial efficacy using a single oral dose of trioxane dimer (6 mg/kg) combined with mefloquine hydrochloride (18 mg/kg) in P. berghei ANKA-infected mice
| trioxane | survival after infection (days) | avg survivala | % parasitemia suppressionb |
|---|---|---|---|
| 12b | 14, 20, 21, 23 | 19.5 | >99.9 |
| 14a | 14, 15, 15, 30 | 18.5 | >99.9 |
| 14b | 13, 23, 30, 30 | 24 | >99.9 |
| |||
| 14d | 23, 21, 23, 30 | 24.3 | >99.9 |
| |||
| 14f | 21, 14, 15, 20 | 17.5 | >99.9 |
| 14g | 23, 21, 21, 30 | 23.8 | >99.9 |
| 14h | 21, 20, 23, 30 | 23.5 | >99.9 |
| 14i | 30, 23, 14, 30 | 24.3 | >99.9 |
| 14j | 27, 20, 21, 30 | 24.5 | >99.9 |
| 14k | 30, 20, 14, 23 | 21.8 | >99.9 |
| |||
| 15a | 23, 20, 21, 29 | 23.3 | >99.9 |
| |||
| 15c | 15, 23, 30, 30 | 24.5 | >99.9 |
| controls: | |||
| vehicle (no drug) | 6, 7, 7, 8 | 7 | 0c |
| artemether (2) 6 mg/kg + mefloquine HCl 18 mg/kg | 23, 27, 13, 23 | 21.5 | >99.9 |
| mefloquine HCl 18 mg/kg alone | 13, 15, 23, 20 | 17.8 | >99.9 |
a
Best results are in bold type.
b
Denotes determination on day 3 after infection.
c
An average of 10% parasitemia was determined on day 3 after infection.