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. 2014 Jun 11;6(6):2340–2375. doi: 10.3390/v6062340

Table 1.

Examples of different measles viruses used for oncolysis including virus modification used for enhanced oncolytic activity/specificity, virus strain and studied tumors/tumor cell lines.

Virus modification Virus strain Tumor/tumor cell line in vitro in vivo References
Measles virus without modification Edmonston human myeloma: ARH-77 cells, RPMI 8226 cells, JJN-3 cells, MM1 cells, KAS-6/1 cells, KMS-11 cells;
primary myeloma cells;
x x [105]
Edmonston human ovarian carcinoma: SKOV3ip.1 cells;
human fibrosarcoma: HT1080 cells;
human epithelial lung carcinoma: A549 cells;
x n.d. [49]
Edmonston
Moraten
human ovarian carcinoma: OV202 cells, OV207 cells, SKOV3ip.1 cells; x x [148]
Edmonston-Zagreb human T-cell lymphoma: SeAx cells, HUT 78 cells, MyLa cells;
cutaneous T-cell lymphomas (CTCL);
x x [149]
Schwarz human mesothelioma: M11 cells, M13 cells, M31 cells, M47 cells, M56 cells, M61 cells; x n.d. [110]
Not detailed human B-precursor acute lymphoblastic leukemia (ALL): 697 cells,
Nalm-6 cells, SEM cells, REH cells;
human Burkitt's lymphoma: Raji cells, Daudi cells;
human T cell leukemia: Jurkat cells;
primary chronic lymphocytic leukemia (CLL) and ALL cells;
x x [150]
CAM-70; Schwarz

MV wild-type: MV190112
human B cell lymphoma: BJAB cells; BJAB cells;
marmoset B-lymphoblastoid: B95-8 cells;
human Burkitt’s lymphoma: Akata cells, BL-41 cells, BL-41/cells, Daudi cells, Mutu cells, Jijoye cells, Namalwa cells, P3HR-1 cells, Raji cells, BLCL cells, LMP1-transduced: BJAB LMP1 cells;
x n.d. [151]
ß-galactosidase reporter gene (MVIacZ) Edmonston human lymphoma: DoHH2 cells, Raji cells; x x [106]
CEA Edmonston human myeloma: RPMI 8226 cells;
human fibrosarcoma: HT1080 cells;
n.d. x [135]
Not detailed human ovarian carcinoma: OV202 cells, OV207 cells, SKOV3ip.1 cells; x x [148]
Edmonston human breast cancer: MDA-MB-231 cells, SkBr3 cells, MCF7 cells; x x [152]
Edmonston human hepatocellular carcinoma: Hep-3B cells, HUH-7 cells; x x [136]
Not detailed human histiocytic lymphoma: U-937 cells;
human Burkitt's lymphoma: Raji cells;
human myeloma: KAS-6/1 cells;
human ovarian carcinoma: SKOV3ip.1 cells;
human hepatocellular carcinoma: HUH-7 cells;
x x [153]
Not detailed human malignant glioma: U87 cells, U251 cells;
primary glioblastoma multiforme: GBM12 cells;
x x [114]
Edmonston-NSe human breast cancer: MDA-MB-231 cells;
human ovarian carcinoma: SKOV3ip.1 cells;
human cerebellar medulloblastoma: TE671 cells;
x n.d. [154]
Edmonston human prostate cancer: PC-3 cells, DU-145 cells, LNCaP cells; x x [155]
Edmonston human ovarian carcinoma: SKOV3ip.1 cells;
human ovarian carcinoma;
x Phase I clinical trial [156]
Edmonston human hepatoblastoma (HB): Hep2G cells, HUH6 cells; x x [24]
Not detailed human glioblastoma: GBM6 cells;
primary human glioblastoma cells;
x x [157]
Not detailed human ovarian carcinoma: SKOV3ip.1 cells; x x [158]
Edmonston human ovarian carcinoma: SKOV3ip.1 cells, IGROV1 cells; OV202 cells; x x [159]
Single chain anti-body CD38 Edmonston human fibrosarcoma: HT1080 cells; x x [121]
Edmonston human glioblastoma: U118 MGcells;
human erythroleukemia: K562 cells;
human Burkitt’s lymphoma: Raji cells, Ramos cells;
human ovarian carcinoma: SKOV3ip.1 cells;
x x [115]
CD20 Replicating MV human fibrosarcoma: HT1080 cells; x x [122]
HER2/neu Not detailed human ovarian carcinoma: SKOV3ip.1 cells;
human medulloblastoma: TE671 cells;
x n.d. [160]
EGFRvIII Edmonston human glioblastoma: U118 MG cells;
human erythroleukemia: K562 cells;
human Burkitt’s lymphoma: Raji cells, Ramos cells;
human ovarian carcinoma: SKOV3ip.1 cells;
x x [115]
Edmonston-NSe human glioblastoma: U118 cells;
primary glioblastoma: GBM6 cells, GBM14 cells, GBM39 cells;
x x [161]
PSMA Edmonston human prostate cancer: LNCaP cells, PC3 cells;
human T cell leukemia: Jurkat cells;
human Burkitt’s lymphoma: Raji cells;
human multiple myeloma: KAS 6/1 cells
x x [162]
CD133 Not detailed Human fibrosarcoma: HT1080 cells;
Human hepatocellular: HuH7 cells;
Primary glioblastoma: NCH644 cells;
x x [51]
GM-CSF Not detailed human Burkitt’s lymphoma: Raji cells; x x [144]
NIS Edmonston human ovarian carcinoma: SKOV3ip.1 cells, IGROV1 cells; OV202 cells; x x [159]
Edmonston Human multiple myeloma: ARH 77 cells, KAS 6/1 cells, MM1 cells; primary myeloma cells; x x [53]
Not detailed human glioblastoma: GBM6 cells;
primary human glioblastoma cells;
x x [157]
Edmonston human multiple myeloma: KAS-6/1 cells; n.d. x [163]
Edmonston human hepatocellular carcinoma: Hep-3B cells, HUH-7 cells; x x [136]
Edmonston human pancreatic cancer: BxPC-3 cells, MiaPaCa-2 cells, Panc-1 cells; x x [164]
Edmonston human prostate cancer: PC-3 cells, DU-145 cells, LNCaP cells; x x [165]
Not detailed human multiple myeloma: MM1 cells, KAS-6/1 cells; x x [166]
Not detailed human pancreatic cancer: BxPC-3 cells; x x [167]
Edmonston human ovarian carcinoma: SKOV3ip.1 cells;
human multiple myeloma: KAS6/1 cells;
x x [168]
Edmonston human malignant glioma: U87 cells, U251 cells;
human primary glioblastoma: GBM6 cells, GBM10 cells, GBM12 cells, GBM39 cells, GBM43 cells, GBM44 cells;
x x [169]
Edmonston human head oral squamous cell carcinoma: SCC-25 cells, SCC-15 cells;
anaplastic human thyroid carcinoma: SW579 cells;
human hypopharyngeal carcinoma: FaDu cells;
x x [170]
Edmonston human medulloblastoma: D283med cells, UW426 cells; x x [54]
Edmonston human head and neck cancer: HN3 cells, HN5 cells, PJ41 cells;
human colorectal cancer: HCT116 cells;
x x [171]
NIS Edmonston human endometrial cancer: HEC-1-A cells, Ishikawa cells, KLE cells, RL95-2 cells, AN3CA cells; ARK-1 cells, ARK-2 cells, SPEC-2 cells; x x [172]
Edmonston B human T-cell lymphoma: SeAx cells, MyLa2059 cells, HUT78 cells; x x [173]
Human IL-13 at the C-terminus of the H-protein Not detailed human malignant glioma: U87, U118, U251 cells; x x [174]
MMP Edmonston B–based parental MV strain (NSe) human fibrosarcoma: HT1080 cells;
human glioblastoma: U87mg cells;
human liver resection material with primary and secondary tumors;
x n.d. [128]
Not detailed human fibrosarcoma: HT1080 cells; x x [125]
αVβ3-integrin targeted (RGD or echistatin domains) Edmonston multiple myeloma xenografts; x x [175]
Not detailed human multiple myeloma: KAS6/1 cells; x x [176]
Human light immunoglobulin chain reporter gene Edmonston Human multiple myeloma: ARH-77 cells, KAS 6/1 cells;
human T cell leukemia: Jurkat cells;
x x [177]
NAP Edmonston human breast cancer: MCF-7 cells, MDA-MB-231 cells; x x [178]
Suicide gene SCD/FCU-1 Not detailed human ovarian carcinoma: OAW42 cells, SKOV3 cells;
primary human ovarian carcinoma cells;
x n.d. [179]
Edmonston B human melanoma: A375M, Mel888, pMelL, and SK-MEL-28 cells; x x [140]
Schwarz human cholangiocarcinoma: RBE, HuCCT1, TFK-1 cells; x x [141]
Not detailed Primary murine and rhesus macaque hepatocytes; x x [143]
Mérieux Human cholangiocarcinoma: HuCCT-1 cells;
Human hepatocellular carcinoma: Hep3B cells;
Human colorectal adenocarcinoma: HCT116 and HCT15 cells;
x n.d. [180]
DARPins EGFR Edmonston human adenocarcinoma: AU565 cells, SK-Br-3;
human breast ductal carcinoma: BT-474 cells, MCF-7 cells;
human colon adenocarcinoma: Caco-2 cells, HT-29 cells, SW-620;
human fibrosarcoma: HT1080 cells;
human ovarian carcinoma: SK-OV-3 cells;
human malignant glioma: U87mg cells;
x x [181]
Her2/neu
EpCAM
MicroRNA-sensitive (containing target sites for microRNA-7 in the 3' untranslated region of the viral fusion gene) Edmonston-B vaccine lineage human malignant glioma: U87 cells;
primary human brain tissue from the peripheral invasion front of a glioma resection;
x x [134]

CD, cluster of differentiation; DARPins, designed ankyrin repeat proteins; EGFR, epidermal growth factor receptor; EpCAM, epithelial cell adhesion molecule; GM-CSF, granulocyte macrophage colony stimulating factor; HER2/neu, human epidermal growth factor receptor 2; IL, interleukin; MMP, matrix metalloproteinase; MV, measles virus; MV-H/hEGF, measles virus H glycoprotein-human epidermal growth factor hybridprotein; n.d., not done; NIS, human thyroidal sodium iodide symporter; PSMA, prostate-specific membrane antigen; SCD, super cytosine deaminase; not detailed, used measles virus strain was not further specified in the Materials and Methods section of the publication.