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. 2014 Jun 16;6(6):2392–2415. doi: 10.3390/v6062392

Table 1.

Alphavirus-based vaccine development for viral targets.

Virus Target Vector/Delivery Immunization Response Reference
BVDV E2 VEE/Particles Calf BVDV protection [23]
NS3 (p80) SFV/DNA Mouse CTL, CMI [24]
CMV gB/pp65-1E1 VEE/Particles Human Phase I Neutralizing Abs [25]
CSFV E2 SFV/DNA Swine CSFV protection [26]
Dengue PrME, E85 VEE/Particles Macaque Dengue protection [27]
Ebola NP VEE/Particles Mouse Ebola protection [21]
NP, GP VEE/Particles Guinea pig Ebola protection [22]
VP24, 30, 35, 30 VEE/Particles Mouse Ebola protection [28]
Hepatitis B cAg SIN/DNA Mouse Specific Abs [29]
sAg SIN/DNA Mouse Specific Abs [29]
Hepatitis C cAg SFV/Particles, DNA Mouse CTL [30]
NS3 SFV/Particles Mouse Cellular [31]
nsPs SFV/Particles Mouse CD8+ T-cell response [32]
HeV Glycoprotein VEE/Particles Mouse Neutralizing Abs [33]
HIV-1 Env SFV/Particles Mouse Humoral [17]
gp41 SFV/Particles Mouse Monoclonal Abs [18]
MA/CA VEE/Particles Mouse Humoral, CTL [19]
HPV 16E7 SFV/DNA Mouse CTL [34]
16E7-VP22 SIN/Particles Mouse CD8+ T-cell response [35]
HSV-1 gpB SIN/Particles Mouse HSV protection [36]
gpB SIN/DNA Mouse CTL, protection [37]
IBDV VP2 SFV/Particles, DNA Chicken Specific Abs [38]
Influenza HA SFV/Particles Mouse Systemic response [15]
HA VEE/Particles Chicken Influenza protection [16]
HA VEE/Particles Swine Influenza protection [20]
NP SFV/Particles, RNA Mouse Humoral, CTL [39]
ISAV HE SAV/Particles Salmon ISAV protection [40]
JEV prM-E, NS1-2A SIN/Particles Mouse JEV Abs [41]
Lassa N VEE/Particles Mouse Immune response [42]
LIV prME SFV/Particles Mouse LIV protection [43]
prME, NS1 SFV/Particles Sheep LIV protection [44]
MBGV GP, NP, VP35 VEE/Particles Guinea pig MBGV protection [45]
GP, NP VEE/Particles Macaque MBGV protection [46]
Measles HA, FUd SIN/DNA Mouse Measles protection [47]
HA, FUd SIN-VEE/Particles Macaque Measles protection [48]
MVE prME, E SFV/Particles Mouse Neutralizing Abs [49]
NiV Glycoproteins VEE/Particles Mouse Neutralizing Abs [33]
NLV VLP VEE/Particles Mouse Immune response [50]
Rabies G SIN/DNA Mouse Rabies protection [51]
RSV F, G SFV/DNA, RNA Mouse RSV protection [52]
F, G SFV/Particles Mouse RSV protection [53]
RVFV Gn VEE/Particles Mouse RVFV protection [54]
SARS-CoV Glycoprotein VEE/Particles Mouse SARS-CoV protection [55]
SEOV M, S SIN/Particles, DNA Hamster SEOV protection [56]
SHIV Env SFV/Particles Macaque T-cell proliferative response [57]
SUDV GP VEE/Particles Primate SUDV protection [58]
Vaccinia A33R, B5R VEE/Particles Mouse Vaccinia protection [59]

Abbreviations: Abs, antibodies; BVDV, bovine viral diarrhea virus; CMI, cell-mediated immune response; CMV, cytomegalovirus; CSFV, classical swine fever virus; CTL, cytotoxic T-lymphocyte activity; HBV, hepatitis B virus; HBC, hepatitis C virus; HE, hemagglutinin-esterase; HeV, Hendra virus; HIV, human immunodeficiency virus; HPV, human papillomavirus; HSV, herpes simplex virus; IBDV, infectious bursal disease virus; ISAV, infectious salmon anemia virus; JEV, Japanese encephalitis virus; LIV, Louping-ill virus; MBGV, Marburg virus; MVE, Murray Valley encephalitis virus; NiV, Nipah virus; NLV, Norwalk-like virus; RSV, respiratory syncytial virus; RVFV, Rift Valley fever virus; SARS‑CoV, severe acute respiratory syndrome corona virus; SAV, salmon anemia virus; SEOV, Seoul virus; SFV, Semliki Forest virus; SHIV, simian-human immunodeficiency virus; SIN, Sindbis virus; SUDV, Sudan virus; VEE, Venezuelan equine encephalitis virus.