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. Author manuscript; available in PMC: 2014 Jun 30.
Published in final edited form as: J Bone Miner Res. 2014 May;29(5):1258–1268. doi: 10.1002/jbmr.2139

Fig. 5.

Fig. 5

A–D panel 2 shows wild-type controls with little to no YM1 immunostaining YM1 indicates that inflammation is present in D469del-COMP cartilages and is exacerbated by exercise. Panel 1: Tibias from P28 mice were collected and immunostained with YM1 antibodies. The D469del-COMP growth plate and articular cartilage showed elevated YM1 immunostaining (C, D) compared to the C57BL/6 controls (A, B). Panel 2: D469del-COMP and control C67BL/6 mice were administered DOX and housed with (runner) and without (non-runner) access to a running wheel from P21 to P42. Tibias were collected at P42 and immunostained for YM1. Running increased expression of YM1 in the D469del-COMP articular cartilage (E compared to F, G, and H). Bar = 100 μm.