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. Author manuscript; available in PMC: 2014 Jun 30.
Published in final edited form as: J Am Soc Nephrol. 2009 Sep 3;20(12):2503–2512. doi: 10.1681/ASN.2009070721

Figure 2.

Figure 2

Morphologically advanced murine diabetic nephropathy demonstrating prominant mesangiolysis. A. There are broad areas of lucency (arrows) within expanded mesangial regions. Mesangiolysis is most easily recognized with a Jones’ silver methenamine stain, in which the normally homogeneous and compact silver staining (black) matrix (shown in Figure 1A) is disrupted as indicated by areas of lucency and/or spongiform appearance. B. In contrast, a PAS stain shows equivalent mesangial expansion, but the demarcation of cellular and matrix components and lytic regions is less distinct with this stain as compared to the Jones’ stain.