Table 1.
Physiological parameters during subpressor dosage of Angll infusion over 4 weeks
| Group | 0 day |
14 day |
28 day |
||||||
|---|---|---|---|---|---|---|---|---|---|
| BW(g) | HR (beats/min) | SBP (mmHg) | BW(g) | HR (beats/min) | SBP (mmHg) | BW (g) | HR (beats/min) | SBP (mmHg) | |
| WT +saline (n = 10) | 24.7 ± 2.2 | 666 ± 46 | 112.6 ± 6.3 | 27.6 ± 2.4 | 687 ± 58 | 115.2 ±5.5 | 29.4 ± 2.7 | 702 ± 61 | 117.0 ± 2.7 |
| WT +Angll (n = 15) | 23.9 ± 1.8 | 645±71 | 116.0 ± 10.1 | 28.3±1.6 | 701 ± 46 | 116.2 ± 3.7 | 29.6 ± 1.5 | 13 ± 59 | 115.4 ± 9.4 |
| Fbln2+/- +saline (n = 7) | 24.2 ± 0.9 | 645 ± 31 | 110.4 ± 3.7 | 27.1 ± 0.5 | 672 ± 52 | 114.2 ± 3.8 | 28.6 ± 1.0 | 695 ± 58 | 114.7 ± 9.3 |
| Fbln+/- + Angll (n = 7) | 24.1 ± 0.5 | 669 ± 64 | 112.3 ± 5.9 | 27.2 ± 0.5 | 688 ± 39 | 116.2 ± 6.1 | 28.7 ± 0.5 | 703 ± 42 | 117.9 ± 4.0 |
| Fbln2-/- +sallne (n = 10) | 24.2 ±2.3 | 660 ±53 | 113.4±8.9 | 27.4±3.0 | 697 ±44 | 120.2 ±3.6 | 28.0±1.2 | 697 ±57 | 119.6±5.7 |
| Fbln2-/- + Angll (n = 15) | 25.4±2.4 | 658 ±63 | 114.2±8.6 | 28.2± 1.8 | 664 ±67 | 123.2 ±6.4 | 29.6±1.9 | 684 ± 44 | 120.4±3.2 |