Table 1.
Summary of current clinical trials with refinements in islet transplantation
| Category | Trial ID | Description | Institution | Estimated completion date |
|---|---|---|---|---|
| Islet alone | NCT00434811 | Islet transplantation in type 1 diabetes – phase 3 (CIT-07) | National Institute of Allergy and Infectious Diseases | May 2014 |
| Islet – Kidney | NCT01123187 | Islet cell transplantation in patients with type 1 diabetes with previous kidney transplantation | University Hospital, Lille | March 2015 |
| NCT01241864 | Islet transplantation in type 1 diabetic kidney allograft | University of Chicago | December 2016 | |
| NCT01705899 | Islet allotransplantation in type 1 diabetes: phase I trial comparing islet alone vs islet after kidney transplantation | Ohio State University | May 2017 | |
| NCT00784966 | Islet after kidney transplant for type 1 diabetes | Virginia Commonwealth University | September 2017 | |
| NCT00468117 | Efficacy of islet after kidney transplantation – phase 3 (CIT-06) | National Institute of Allergy and Infectious Diseases | December 2018 | |
| Alternative transplant sites | NCT00790257 | Safety and efficacy study of encapsulated human islets allotransplantation to treat type 1 diabetes (subcutaneous space) | Cliniques universitaires Saint Luc Université Catholique de Louvain | December 2013 |
| NCT01722682 | Bone marrow versus liver as site for islet transplantation | Ospedale San Raffaele | November 2014 | |
| NCT01652911 | A phase I/II study of the safety and efficacy of sernova’s Cell Pouch™ for therapeutic islet transplantation (subcutaneous space) | University of Alberta | December 2014 | |
| NCT01379729 | Functional survival of beta cell allografts after transplantation in the peritoneal cavity of non-uremic type 1 diabetic patients | Ziekenhuis Brussel/Ziekenhuizen Leuven Belgium | May 2018 | |
| Complications | NCT01148680 | Trial comparing metabolic efficiency of islet graft to intensive insulin therapy for type 1 diabetes treatment | University Hospital, Grenoble | December 2014 |
| NCT00853424 | A comparison of islet cell transplantation with medical therapy for the treatment of diabetic eye disease | University of British Columbia | June 2015 | |
| Refined portal vein protocols | NCT00679042 | Islet transplantation in type 1 diabetic patients using the University of Illinois at Chicago protocol | University of Illinois | December 2013 |
| NCT00789308 | Safety and effectiveness of low molecular weight sulfated dextran in islet transplantation | National Institute of Allergy and Infectious Diseases | August 2014 | |
| NCT01817959 | Study to assess efficacy and safety of reparixin in pancreatic islet transplantation | Multi-Centers International | November 2014 | |
| NCT00530686 | Pancreatic islet cell transplantation – a novel approach to improve islet quality and engraftment | Baylor Research Institute | December 2014 | |
| NCT01653899 | Caspase inhibition in islet transplantation | University of Alberta | June 2015 | |
| NCT01897688 | A phase 2 single center study of islet transplantation in non-uremic diabetic patients | Northwestern University | June 2015 | |
| NCT01186562 | Sitagliptin therapy to improve outcomes after islet autotransplant | University of Minnesota | September 2015 | |
| NCT01630850 | Islet transplantation in patients with (brittle) type 1 diabetes | University of Chicago | June 2019 | |
| NCT01974674 | Allogeneic islet transplantation for the treatment of type 1 diabetes (GRIIF) | Assistance Publique – Hôpitaux de Paris | January 2021 | |
| NCT01909245 | Islet cell transplant for type 1 diabetes (TCD) | City of Hope Medical Center | July 2021 | |
| Alternative cellular therapies | NCT00646724 | Co-transplantation of islet and mesenchymal stem cell in type 1 diabetic patients | Fuzhou General Hospital | January 2014 |
| NCT01350219 | Stem cell educator therapy in type 1 diabetes | Tianhe Stem Cell Biotechnologies Inc. | September 2014 | |
| NCT01736228 | Open-label investigation of the safety and efficacy of DIABECELL in patients with T1DM: xenotransplantation of encapsulated porcine islets into the peritoneal cavity | Living Cell Technologies | December 2014 | |
| NCT01341899 | Efficacy and safety study of autologous hematopoietic stem cell transplantation to treat new onset type 1 diabetes | Nanjing University Medical School | December 2015 | |
| NCT01285934 | A trial of high dose immunosuppression and autologous hematopoietic stem cell support versus intensive insulin therapy in adults with early onset T1DM | University of Sao Paulo General Hospital | December 2016 |
Abbreviations: CIT, Clinical Islet Transplant; GRIIF, allogeneic islet transplantation for the treatment of type 1 diabetes; T1DM, type I diabetes mellitus; TCD, T-cell depletion.