Table 1.
Baseline patient characteristics, demographics, and infection characteristics
| Characteristic | Patients (n = 173) a |
|---|---|
| Age, years |
59 ± 16 |
| Male, n (%) |
93 (54) |
| Caucasian, n (%) |
164 (95) |
| Body mass index, kg/m2 |
25.5 ± 3.6 |
| Body surface area, m2 |
1.9 ± 0.2 |
| Non-operative admission diagnosis, n (%) |
110 (65) |
| Intensive care unit, n (%) |
37 (22) |
| Renal parameters |
|
| History of moderate to severe kidney disease, n (%) |
22 (13) |
| Serum creatinine, mg/dLb |
0.8 ± 0.4 |
| Cystatin C, mg/L |
1.1 ± 0.5 |
| eGFR, mL/minc |
|
| Cockcroft-Gault |
108 ± 48 |
| CKD-EPIcreatinine |
98 ± 29 |
| CKD-EPIcystatin C |
84 ± 37 |
| CKD-EPIcreatinine-cystatin C |
91 ± 33 |
| Infectious source, n (%)d |
|
| Pulmonary |
50 (29) |
| Bacteremia |
36 (21) |
| Intra-abdominal |
28 (16) |
| Skin and soft tissue infection |
28 (16) |
| Musculoskeletal |
27 (16) |
| Other/unknowne |
43 (25) |
| Microbiology |
|
| Culture positive, n (%) |
98 (57) |
| Monomicrobial |
51 |
| Specific Gram-positive organisms isolated |
|
| Coagulase-negative Staphylococcus spp. |
25 |
| Methicillin-susceptible Staphylococcus aureus |
15 |
| Methicillin-resistant S. aureus |
10 |
| Enterococcus spp. |
22 |
| Vancomycin |
|
| Loading dose used, n (%) |
64 (37) |
| Maintenance dose |
|
| Non-weight based, mg |
1,206 ± 263 |
| Weight-based, mg/kg |
16.3 ± 2.4 |
| Dose between 14 and 21 mg/kg, n (%) |
152 (88) |
| Interval, n (%) |
|
| 8 hours |
8 (5) |
| 12 hours |
148 (86) |
| 24 hours |
17 (10) |
| Goal trough according to site of infection |
|
| 10-15 mg/L, n (%) |
69 (40) |
| 15-20 mg/L, n (%) |
104 (60) |
| Trough level, mg/L | 12.5 ± 6.0 |
aValues expressed as mean ± standard deviation unless noted. bTo convert the values for serum creatinine to micromoles per liter, multiply by 88.4. cTo convert from mL/min per 1.732 multiply by [(0.007184*height (cm)0.725*weight (kg)0.425)/1.73] [37]. dSum of percentages exceeds 100 due to multiple sources of suspected/documented infection. eOther sources include genitourinary, febrile neutropenia, cardiovascular, central nervous system, acute otitis media, and prophylaxis. CKD-EPI, Chronic Kidney Disease Epidemiology Collaborative; eGFR, estimated glomerular filtration rate; n, number.