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. 2014 May 29;18(3):R110. doi: 10.1186/cc13899

Table 3.

Predictive models for vancomycin trough level, mg/L

Model variable a Beta P value Model fit ( R 2 ) Target trough achievement (95% CI)
Model 1: log creatinine
  
  
 0.306
 35% (28%-42%)
  Intercept
 9.10
 0.002
  
  Age, years
 0.0886
 0.002
  Male
 −2.30
 0.02
  Weight, kg
 −0.0136
 0.004
  Vancomycin total dose, g
 3.28
 <0.001
  Every 8-hour interval
 3.18
 0.1
  Every 12-hour interval
 REF
 -
  Every 24-hour interval
 −6.61
 <0.001
  Log baseline creatinine
 8.80
 <0.001
Model 2: log cystatin C
  
  
 0.559
 52% (45%-59%)
  Intercept
 10.2
 <0.001
  
  Age, years
 −0.00578
 0.8
  Male
 −2.32
 0.004
  Weight, kg
 −0.0708
 0.05
  Vancomycin total dose, g
 2.50
 <0.001
  Every 8-hour interval
 4.25
 0.009
  Every 12-hour interval
 REF
 -
  Every 24-hour interval
 −6.66
 <0.001
  Log baseline cystatin C
 12.6
 <0.001
Model 3: log creatinine and log cystatin C
  
  
 0.575
 53% (45%-60%)
  Intercept
 11.5
 <0.001
  
  Age, years
 0.00582
 0.8
  Male
 −2.64
 0.001
  Weight, kg
 −0.0931
 0.01
  Vancomycin total dose, g
 2.70
 <0.001
  Every 8-hour interval
 4.15
 0.009
  Every 12-hour interval
 REF
 -
  Every 24-hour interval
 −7.90
 <0.001
  Log baseline creatinine
 2.89
 0.01
  Log baseline cystatin C
 11.3
 <0.001
Model 4: eGFR with Cockcroft-Gault
  
  
 0.269
 33% (26% - 40%)
  Intercept
 10.3
 <0.001
  
  Vancomycin total dose, g
 2.66
 <0.001
  Every 8-hour interval
 3.20
 0.1
  Every 12-hour interval
 REF
 -
  Every 24-hour interval
 −4.11
 0.008
  eGFR with Cockcroft-Gault, mL/min
 −0.0704
 <0.001
Model 5: eGFR with CKD-EPI creatinine
 
  
 0.394
 38% (31%-46%)
  Intercept
 16.4
 <0.001
  
  Vancomycin total dose, g
 3.35
 <0.001
  Every 8-hour interval
 3.47
 0.06
  Every 12-hour interval
 REF
 -
  Every 24-hour interval
 −7.58
 <0.001
  eGFR with CKD-EPIcreatinine, mL/minb
 −0.163
 <0.001
Model 6: eGFR with CKD-EPI cystatin C
 
  
 0.538
 51% (44%-59%)
  Intercept
 14.3
 <0.001
  
  Vancomycin total dose, g
 2.61
 <0.001
  Every 8-hour interval
 4.91
 <0.001
  Every 12-hour interval
 REF
 -
  Every 24-hour interval
 −5.94
 <0.001
  eGFR with CKD-EPIcystatin C, mL/minb
 −0.134
 <0.001
Model 7: eGFR with CKD-EPI creatinine-cystatin C
 
  
 0.580 54% (45%-61%)
  Intercept
 16.7
 <0.001
  
  Vancomycin total dose, g
 2.95
 <0.001
  Every 8-hour interval
 4.84
 0.002
  Every 12-hour interval
 REF
 -
  Every 24-hour interval
 −7.70
 <0.001
  eGFR with CKD-EPIcreatinine-cystatin C, mL/minb −0.163 <0.001

aVancomycin total dose represents the cumulative grams of vancomycin given prior to trough level being drawn. Per the study definition, this represents three doses of vancomycin therapy. bTo convert from milliliters per minute per 1.732, multiply by [(0.007184*height (cm)0.725*weight (kg)0.425)/1.73] [37]. CI, confidence interval; CKD-EPI, Chronic Kidney Disease Epidemiology Collaborative; eGFR, estimated glomerular filtration rate; REF, reference.