Table 1.
Patients with suspected VAP
|
Overall |
Statin previous users |
Statin-naive patients |
P | |
|---|---|---|---|---|
| (n = 349) | (n = 93) | (n = 256) | ||
| Age (years) |
64.0 (17.0-94.0) |
68.0 (27.0-90.0) |
63.0 (17.0-94.0) |
<0.01 |
| SAPS II |
50.0 (6.0-109.0) |
54.0 (18.0-109.0) |
49.0 (6.0-99.0)) |
0.06 |
| Gender, male (n (%)) |
254 (72.8) |
80 (86.0) |
174 (68.0) |
<0.01 |
| Hospitalization prior to ICU admission (n (%)) |
347 (62.3) |
89 (67.9) |
258 (60.6) |
0.14 |
| Underlying disease(s) | ||||
| COPD (n (%)) |
99 (17.7) |
33 (25.1) |
66 (15.5) |
0.01 |
| Chronic renal failure (n (%)) |
23 (6.6) |
10 (10.9) |
13 (5.1) |
0.05 |
| Chronic cardiac disease (n (%)) |
138 (39.6) |
65 (70.6) |
73 (28.5) |
<0.01 |
| Diabetes mellitus (n (%)) |
67 (19.2) |
29 (31.5) |
38 (14.8) |
<0.01 |
| Cirrhosis (n (%)) |
17 (4.9) |
2 (2.2) |
15 (5.9) |
0.16 |
| Immunosuppression (excepting steroids) (n (%)) |
17 (4.9) |
4 (4.3) |
13 (5.1) |
0.78 |
| Steroids (n (%)) |
20 (5.8) |
8 (8.7) |
12 (4.7) |
0.16 |
| Cancer (n (%)) |
31 (8.9) |
10 (10.9) |
21 (8.2) |
0.44 |
| Nursing-home resident (n (%)) |
16 (4.6) |
2 (2.1) |
14 (5.5) |
0.19 |
| Main admission diagnosis |
|
|
|
0.20 |
| Respiratory distress (n (%)) |
133 (38.1) |
33 (35.5) |
100 (39.1) |
0.54 |
| Extrapulmonary sepsis (n (%)) |
107 (30.6) |
33 (35.5) |
74 (69.2) |
0.24 |
| Neurologic failure (n (%)) |
50 (14.3) |
10 (10.7) |
40 (15.6) |
0.24 |
| Abdominal surgery (n (%)) |
17 (4.9) |
2 (2.1) |
15 (5.8) |
0.15 |
| Miscellaneous (n (%)) | 42 (12.0) | 15 (16.1) | 27 (10.5) | 0.16 |
Baseline characteristics according to statin exposure. VAP, ventilator-associated pneumonia; SAPS II, simplified acute physiology score II; ICU, intensive care unit; COPD, chronic obstructive pulmonary disease; MV, mechanical ventilation.