Table 3.
Baseline characteristics and suspected VAP episode description of the study patients according to the 30-day mortality
|
Survivors |
Nonsurvivors |
P | |
|---|---|---|---|
| (n = 249) | (n = 100) | ||
| Age (years) |
62.0 (17.0-94.0) |
68.5 (32.0-90.0) |
<0.01 |
| SAPS II (points) |
47.0 (6.0-109.0) |
55.0 (15.0-99.0) |
<0.01 |
| Gender, male (n (%)) |
182 (73.1) |
72 (72.0) |
0.83 |
| Underlying disease(s) (n (%)) |
|
|
|
| Chronic renal failure |
12 (4.8) |
11 (11.0) |
0.04 |
| Cardiac chronic disease |
84 (33.9) |
54 (54.0) |
<0.01 |
| Diabetes mellitus |
45 (18.1) |
22 (22.0) |
0.41 |
| COPD |
45 (18.1) |
21 (21.0) |
0.53 |
| Cirrhosis |
6 (2.4) |
11 (11.0) |
<0.01 |
| Immunosuppression |
9 (3.6) |
8 (8.0) |
0.09 |
| Cancer |
25 (10.1) |
6 (6.0) |
0.21 |
| Nursing-home resident (n (%)) |
16 (6.4) |
0 (0.0) |
<0.01 |
| Main admission diagnosis |
|
|
0.02 |
| Respiratory distress (n (%)) |
101 (40.6) |
32 (32.0) |
0.13 |
| Extrapulmonary sepsis (n (%)) |
64 (25.7) |
43 (43.0) |
<0.01 |
| Neurologic failure (n (%)) |
40 (16.1) |
10 (10.0) |
0.14 |
| Abdominal surgery (n (%)) |
14 (5.6) |
3 (3.0) |
0.30 |
| Miscellaneous (n (%)) |
30 (12.0) |
12 (12.0) |
0.99 |
| CPIS day 1 |
6.0 (2.0-11.0) |
5.0 (3.0-9.0) |
0.06 |
| CPIS day 3 |
7.0 (5.0-13.0) |
7.0 (5.0-11.0) |
0.20 |
| SOFA day 1 |
7.0 (4.0-17.0) |
10.0 (4.0-16.0) |
<0.01 |
| SOFA day 3 |
7.0 (4.0-16.0) |
9.0 (4.0-18.0) |
<0.01 |
| Length of ICU stay until VAP (days) |
10.0 (2.0-157.0) |
11.0 (2.0-72.0) |
0.48 |
| Duration of MV until VAP (days) |
10.0 (2.0-156.0) |
10.0 (2.0-70.0) |
0.37 |
| Septic shock (VAP day 1) (n (%)) |
71 (28.6) |
46 (46.0) |
<0.01 |
| Late-onset VAP (≥5 days after MV onset) (n (%)) |
166 (66.7) |
75 (75.0) |
0.13 |
| MDR bacteria (n (%)) |
76 (30.8) |
41 (41.0) |
0.05 |
| Appropriate antibiotic therapy within the first 24 hours of VAP (n (%)) |
193 (78.4) |
69 (69.0) |
0.16 |
| Steroids during VAP period (n (%)) |
89 (36.8) |
64 (64.0) |
<0.01 |
| Statin exposure prior to ICU admission (n (%)) |
60 (24.1) |
33 (33.0) |
0.09 |
| Statin continuation after ICU admission (n (%)) | 37 (14.8) | 15 (15.0) | 0.97 |
VAP, ventilator-associated pneumonia; SAPS II, simplified acute physiology score II; COPD, chronic obstructive pulmonary disease; CPIS, clinical pulmonary infection score; SOFA, sequential organ failure assessment; ICU, intensive care unit; MV, mechanical ventilation; MDR, multidrug resistant.