Table 5.
Patients with suspected VAP and previous exposure to statins
|
Statin continuation |
Statin discontinuation |
P | |
|---|---|---|---|
| (n = 52) | (n = 41) | ||
| Age (years) |
67.5 (27.0-85.0) |
68.0 (46.0-90.0) |
0.99 |
| SAPS II |
51.0 (18.0-109.0) |
55.0 (24.0-91.0) |
0.56 |
| Gender, male (n (%)) |
44 (84.6) |
36 (87.8) |
0.66 |
| Hospitalization prior to ICU admission (n (%)) |
31 (59.6) |
33 (80.5) |
0.03 |
| Underlying disease(s) | |||
| COPD (n (%)) |
10 (19.2) |
14 (34.1) |
0.10 |
| Chronic renal failure (n (%)) |
6 (11.8) |
4 (9.7) |
0.76 |
| Chronic cardiac disease (n (%)) |
37 (72.5) |
28 (68.3) |
0.66 |
| Diabetes mellitus (n (%)) |
20 (39.2) |
9 (21.9) |
0.07 |
| Cirrhosis (n (%)) |
0 (0.0) |
2 (4.9) |
0.11 |
| Immunosuppression (excepting steroids) (n (%)) |
2 (4.9) |
2 (3.9) |
0.82 |
| Steroids (n (%)) |
5 (9.8) |
3 (7.3) |
0.67 |
| Cancer (n (%)) |
6 (11.8) |
4 (9.8) |
0.76 |
| Nursing-home resident (n (%)) |
1 (1.9) |
1 (2.4) |
0.86 |
| Main admission diagnosis |
|
|
0.20 |
| Respiratory distress (n (%)) |
22 (42.3) |
11 (26.8) |
0.12 |
| Extrapulmonary sepsis (n (%)) |
15 (28.8) |
18 (43.9) |
0.13 |
| Neurologic failure (n (%)) |
4 (7.7) |
6 (14.6) |
0.28 |
| Abdominal surgery (n (%)) |
0 (0.0) |
2 (4.9) |
0.11 |
| Miscellaneous (n (%)) |
11 (21.1) |
4 (9.8) |
0.14 |
| Renal failure on admission (Yes (%)) |
29 (55.8) |
21 (51.2) |
0.66 |
| Nasogastric tube (Yes (%)) | 52 (100) | 39 (95.1) | 0.11 |
Baseline characteristics according to statin continuation. VAP, ventilator-associated pneumonia; SAPS II, simplified acute physiology score II; ICU, intensive care unit; COPD, chronic obstructive pulmonary disease.