Table 1. Recommendations for emergency drug treatment in patients with anaphylaxis (adapted from Ring et al. [12]).
Drug substance | Application route and dosage |
---|---|
Epinephrine | Autoinjector for intramuscular administration, weight-adjusted: >10 kg 150 µg epinephrine >30 kg 300 µg epinephrine |
Antihistamine | Depending on patient age and preference, oral as a fluid or as (soluble) tablets; the permitted daily dose of any antihistamine can be recommended as a single dose. For dimetindene drops, similarly, a weight-adjusted dosage of the i.v. formulation can be recommended as dose to be taken orally |
Corticosteroid | Depending on patient age and preference, rectal or oral (as fluid or tablets) 50–100 mg prednisolone-equivalent dose |
Optional β-mimetic, e.g., salbutamol | In patients with known bronchial asthma: β2-sympathomimetic; in patients with expected obstruction of the airways: inhalational epinephrine preparation with spray head for drug vial (ask the pharmacist) |
Note: An emergency kit for immediate treatment should include written instructions for using the medication (e.g., anaphylaxis card and/or anaphylaxis emergency plan)