TABLE 1.
Source of cells | Culture age (days) | Total nuclei | Number of fields | Nuclei in E+V+ cells
|
Nuclei in V+ cells
|
Total+ cells
|
|||
---|---|---|---|---|---|---|---|---|---|
Myotube | Myocyte | Myotube | Myocyte | Myotube | Myocyte | ||||
E14 | 1 | 500 | 47 | 4 | 30 | 2 | 4 | 6 | 34 |
510 | 45 | 4 | 24 | 0 | 0 | 4 | 24 | ||
2 | 516 | 12 | 12 | 34 | 0 | 13 | 12 | 47 | |
530 | 15 | 9 | 24 | 4 | 6 | 13 | 30 | ||
3 | 967 | 10 | 499 | 39 | 0 | 18 | 499 | 57 | |
752 | 10 | 426 | 39 | 3 | 6 | 429 | 45 | ||
4 | 981 | 10 | 466 | 6 | 10 | 4 | 476 | 10 | |
1359 | 10 | 628 | 3 | 3 | 7 | 631 | 10 | ||
5 | 1836 | 10 | 824 | 8 | 19 | 22 | 843 | 30 | |
2206 | 10 | 1061 | 6 | 24 | 20 | 1085 | 26 | ||
E18 | 1 | 501 | 42 | 0 | 0 | 0 | 0 | 0 | 0 |
504 | 42 | 0 | 0 | 0 | 0 | 0 | 0 | ||
2 | 506 | 31 | 0 | 0 | 0 | 2 | 0 | 2 | |
511 | 28 | 0 | 0 | 0 | 0 | 0 | 0 | ||
3 | 505 | 14 | 3 | 0 | 0 | 3 | 3 | 3 | |
501 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | ||
4 | 1097 | 10 | 0 | 0 | 11 | 28 | 11 | 28 | |
942 | 10 | 0 | 2 | 4 | 29 | 4 | 31 | ||
4.5 | 1518 | 10 | 30 | 1 | 184 | 75 | 214 | 76 | |
1445 | 10 | 37 | 0 | 160 | 45 | 197 | 45 | ||
5 | 1635 | 10 | 475 | 12 | 382 | 59 | 857 | 71 | |
2009 | 10 | 694 | 5 | 349 | 53 | 1043 | 58 | ||
6* | 552 | 10 | 183 | 0 | 3 | 4 | 186 | 4 | |
572 | 10 | 207 | 1 | 0 | 1 | 207 | 2 | ||
1-day | 1 | 500 | 104 | 0 | 0 | 0 | 0 | 0 | 0 |
501 | 95 | 0 | 0 | 0 | 0 | 0 | 0 | ||
2 | 504 | 60 | 0 | 0 | 0 | 0 | 0 | 0 | |
506 | 69 | 0 | 0 | 0 | 0 | 0 | 0 | ||
3 | 503 | 25 | 0 | 0 | 0 | 0 | 0 | 0 | |
519 | 26 | 0 | 0 | 0 | 0 | 0 | 0 | ||
4 | 507 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | |
525 | 15 | 0 | 0 | 4 | 3 | 4 | 3 | ||
5 | 1002 | 10 | 0 | 0 | 0 | 35 | 0 | 35 | |
814 | 10 | 0 | 0 | 0 | 22 | 0 | 22 | ||
6 | 3202 | 10 | 17 | 1 | 314 | 87 | 331 | 88 | |
2097 | 10 | 0 | 0 | 151 | 87 | 151 | 87 | ||
7 | 3637 | 10 | 219 | 0 | 1249 | 59 | 1468 | 59 | |
3632 | 10 | 381 | 1 | 1073 | 35 | 1454 | 36 | ||
8* | 688 | 10 | 195 | 1 | 37 | 3 | 232 | 4 | |
897 | 10 | 234 | 1 | 11 | 0 | 245 | 1 | ||
3-week | 1 | 524 | 37 | 0 | 0 | 0 | 8 | 0 | 8 |
500 | 39 | 0 | 0 | 0 | 0 | 0 | 0 | ||
2 | 505 | 22 | 0 | 0 | 2 | 9 | 2 | 9 | |
513 | 19 | 0 | 0 | 0 | 1 | 0 | 1 | ||
3 | 926 | 10 | 0 | 0 | 0 | 12 | 0 | 12 | |
875 | 10 | 0 | 0 | 2 | 11 | 2 | 11 | ||
4 | 2296 | 10 | 0 | 0 | 383 | 81 | 383 | 81 | |
2258 | 10 | 0 | 0 | 330 | 79 | 330 | 79 | ||
5 | 3072 | 10 | 870 | 0 | 954 | 22 | 1824 | 22 | |
2726 | 10 | 437 | 0 | 1244 | 20 | 1681 | 20 | ||
6* | 893 | 10 | 195 | 0 | 4 | 10 | 109 | 10 | |
867 | 10 | 260 | 0 | 3 | 7 | 260 | 7 |
Note. Duplicate cultures were fixed and double-labeled at each time point with mAbs against embryonic fast MHC (EB165 indirectly labeled with GAM-TRITC) and ventricular MHC (HV11 directly labeled with fluorescein). Nuclei were counterstained with DAPI and the number of nuclei within MHC-positive cells versus total nuclei was determined using a 40X objective, except where indicated (*), when counts were determined using a 100X objective.