Table 1.
Characteristics of 42 critically ill patients receiving vancomycin therapy, stratified for intermittent dosing or continuous infusion
| Characteristic | All patients (n = 42) | Intermittent dosing (n = 18) | Continuous infusion (n = 24) | P * |
|---|---|---|---|---|
| Age (years) |
58 [45 - 66] |
58 [32 - 79] |
58 [45 - 66] |
0.755 |
| Male sex |
27 (64.3) |
13 (72.2) |
14 (58.3) |
0.353 |
| Weight (kg) |
70 [61 - 85] |
75 [65 - 88] |
70 [61 - 85] |
0.350 |
| APACHE II score |
16 [13 - 25] |
17 [14 - 27] |
16 [13 - 25] |
0.920 |
| SOFA score |
6 [3 - 9] |
5 [3 - 6] |
6 [3 - 9] |
0.595 |
| Serum creatinine concentration (μmol/L) |
65 [51 - 113] |
64 [52 - 91] |
74 [44 - 129] |
0.751 |
| Urinary creatinine clearance (mL/min.) |
85 [60 - 106] |
72 [20 - 90] |
101 [74 - 167] |
0.198 |
| Renal replacement therapy |
9 (21.4) |
1 (5.6) |
8 (33.3) |
NA |
| Intermittent hemodialysis |
2 (4.8) |
0 |
2 |
|
| Continuous renal replacement therapy | 7 (16.7) | 1 | 6 |
Data are described as median [1st - 3rd quartile] or n (%). *Indicates difference between intermittent dosing and continuous infusion of vancomycin. APACHE II, acute physiology and chronic health evaluation II; SOFA, sequential organ failure assessment; NA, not applicable as the expected count in at least one cell is less than 5.