Table 2.

Antibiotics Used for Patients in Re-Treatment Trials of Lyme Disease

Study authors (Reference)	Antibiotic inclusion criteria	Antibiotic exclusion criteria	Past use of antibiotics	Antibiotic use in the clinical trial
Klempner et al. (1)	Must have received a course of antibiotics for Lyme disease	Allergy; ≥60 days of parenteral antibiotics	33% prior IV antibiotics for mean of 30 days; median duration of prior total antibiotic use >50 days	Ceftriaxone 2 g IV/day × 30 days followed by doxycycline 100 mg twice daily × 60 days
Krupp et al. (3)	Must have been treated for Lyme disease with ≥3 weeks of oral or IV antibiotics	Allergy	47.3% prior IV ceftriaxone for ≥3 weeks; mean duration of prior total antibiotic use >50 days	Ceftriaxone 2 g IV/day × 28 days
Fallon et al. (4)	Must have been treated for Lyme disease with ≥3 weeks of ceftriaxone completed ≥4 months before study entry	Allergy	100% prior IV antibiotics for a mean of 69 days plus a mean of 216 days of oral antibiotics	Ceftriaxone 2 g IV/day × 70 days