Table 1. Four pathological metrics of healing: 1. condition of endothelium covering, 2. residual thrombus, 3. connective tissue, and 4. lumen narrowing.
1. For characterization of endothelium covering, the ideal condition is defined as 100% endothelium coverage of the aneurysm ostium (score = 0). The following conditions are the intermediate gradations between ideal and less than ideal listed in descending order: greater than 95% endothelium coverage (score = 1), 90–95% endothelium coverage (score = 2), 80–-89% endothelium coverage (score = 3). The less than ideal condition is defined as <80% coverage (score = 4) determined by LV-SEM. 2. For characterization of thrombus the ideal condition is defined as 0% of SMP foam surface covered by thrombus (score = 0). The following conditions are the intermediate gradations between Ideal and less than ideal listed in descending order: <1% covered by thrombus (score = 1), 1–4% covered by thrombus (score = 2), 5–10% covered by thrombus (score = 3). Less than ideal was defined as >10% covered by thrombus (score = 4) determined by histology. 3. For characterization of Connective Tissue the ideal condition is defined as the aneurysm being 100% composed of connective tissue (score = 0). The following conditions are the intermediate gradations between ideal and less than ideal listed in descending order: 75% composed of connective tissue (score = 1), 50% composed of connective tissue (score = 2), 25% composed of connective tissue (score = 3). Less than ideal was defined as 0% (score = 4) composed of connective tissue determined by histology. 4. For characterization of lumen narrowing the ideal was defined as a lack of lumen narrowing (score = 0). Intermediate gradations between ideal and less than ideal listed in descending order: <5% lumen narrowing (score = 1), 5–20% lumen narrowing (score = 2), 20–35% lumen narrowing (score = 3). Less than ideal was defined as >35% lumen narrowing (score = 4) determined by LV-SEM and histology.
30 days, n = 7 | 90 days, n = 8 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
1. endothelium covering | 0% | 25% | 50% | 25% | 0% | 0% | 0% | 0% | 0% | 100% |
2. residual thrombus | 0% | 0% | 0% | 43% | 57% | 0% | 0% | 0% | 0% | 100% |
3. connective tissue | 0% | 57% | 14% | 29% | 0% | 0% | 0% | 0% | 0% | 100% |
4. lumen narrowing | 0% | 0% | 29% | 71% | 0% | 0% | 0% | 0% | 100% | 0% |
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