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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: J Biomed Mater Res A. 2013 May 23;102(5):1231–1242. doi: 10.1002/jbm.a.34782

Table 1. Four pathological metrics of healing: 1. condition of endothelium covering, 2. residual thrombus, 3. connective tissue, and 4. lumen narrowing.

1. For characterization of endothelium covering, the ideal condition is defined as 100% endothelium coverage of the aneurysm ostium (score = 0). The following conditions are the intermediate gradations between ideal and less than ideal listed in descending order: greater than 95% endothelium coverage (score = 1), 90–95% endothelium coverage (score = 2), 80–-89% endothelium coverage (score = 3). The less than ideal condition is defined as <80% coverage (score = 4) determined by LV-SEM. 2. For characterization of thrombus the ideal condition is defined as 0% of SMP foam surface covered by thrombus (score = 0). The following conditions are the intermediate gradations between Ideal and less than ideal listed in descending order: <1% covered by thrombus (score = 1), 1–4% covered by thrombus (score = 2), 5–10% covered by thrombus (score = 3). Less than ideal was defined as >10% covered by thrombus (score = 4) determined by histology. 3. For characterization of Connective Tissue the ideal condition is defined as the aneurysm being 100% composed of connective tissue (score = 0). The following conditions are the intermediate gradations between ideal and less than ideal listed in descending order: 75% composed of connective tissue (score = 1), 50% composed of connective tissue (score = 2), 25% composed of connective tissue (score = 3). Less than ideal was defined as 0% (score = 4) composed of connective tissue determined by histology. 4. For characterization of lumen narrowing the ideal was defined as a lack of lumen narrowing (score = 0). Intermediate gradations between ideal and less than ideal listed in descending order: <5% lumen narrowing (score = 1), 5–20% lumen narrowing (score = 2), 20–35% lumen narrowing (score = 3). Less than ideal was defined as >35% lumen narrowing (score = 4) determined by LV-SEM and histology.

30 days, n = 7 90 days, n = 8
1. endothelium covering 0% 25% 50% 25% 0% 0% 0% 0% 0% 100%
2. residual thrombus 0% 0% 0% 43% 57% 0% 0% 0% 0% 100%
3. connective tissue 0% 57% 14% 29% 0% 0% 0% 0% 0% 100%
4. lumen narrowing 0% 0% 29% 71% 0% 0% 0% 0% 100% 0%
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