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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Transl Res. 2013 Apr 6;162(1):45–55. doi: 10.1016/j.trsl.2013.03.005

Figure 1. Effects of Rho kinase and p38 MAPK inhibitors on the development of lung inflammation induced by LTA and PepG.

Figure 1

Figure 1

C57BL/6J mice were treated i.t. with a mixture of LTA (2.5 mg/kg) and PepG (2.5 mg/kg), with or without concurrent i.v. treatment with Y27632 (2 mg/kg), SB203580 (10 mg/kg) for 24 hours. Control animals were treated with sterile saline solution. A - Protein concentration; B - Total cell count; and C - Neutrophil count were measured in bronchoalveolar lavage fluid taken from control and experimental animals, n=6 per condition; *p<0.05. D – Histological analysis of lung tissue (×40 magnification). Whole lungs (4 to 6 animals from each experimental group) were agarose-inflated in situ, fixed with 10% formalin, and used for hematoxylin and eosin staining and histological evaluation.