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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Transl Res. 2013 Apr 6;162(1):45–55. doi: 10.1016/j.trsl.2013.03.005

Figure 4. Effects of p38 MAPK and Rho pathway inhibition on LTA/PepG-induced hyper-permeability in lung macrovascular and microvascular endothelium.

Figure 4

HPAEC or HLMVEC grown on microelectrodes to confluence were pretreated with 20 μM SB203580 (A) or 2 μM Y27632 (B) for 30 min followed by challenge with a combination of LTA (50 ng/ml) and PepG (100 ng/ml) and used for measurements of TER. C - Permeability changes were registered at the time of maximal permeability response (15 hrs post LTA/PepG treatment). Maximal TER decline reflecting endothelial barrier dysfunction induced by LTA/PepG was taken as 100%. Results are shown as mean ± SD, * p<0.05; n=8 experiments.