Table 2.
Thirty-one mitochondrial protein expression changes in ischemic HF summarized from Scaffold analysis with 15 up regulated, and 16 down regulated (p < 0.05). Fold changes in HF is versus respective Sham controls.
| SYMBOL | PROTEIN | Fold Changes | P-value |
|---|---|---|---|
| G5ASL9 | Myosin-6 | 2.811901 | 0.045 |
| NNT | Nicotinamide nucleotide transhydrogenase | 2.259436 | 4E–10 |
| CScs | Citrate synthase | 2.18273 | 0.0043 |
| GW7 | Creatine kinase S-type, mitochondrial | 1.853532 | 3.3E–06 |
| MAOA | Amine oxidase [flavin-containing] A | 1.840772 | 0.000033 |
| MYH7 | Myosin-7 | 1.794734 | 0 |
| SDHC | Succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa |
1.717908 | 0.02 |
| SLC25A11 | Mitochondrial 2-oxoglutarate/malate carrier protein | 1.610646 | 0.0046 |
| ATP5C1 | ATP synthase subunit gamma | 1.592209 | 0.000003 |
| ALDH2 | Aldehyde dehydrogenase, mitochondrial | 1.581248 | 0.0073 |
| IDH2 | Isocitrate dehydrogenase [NADP], mitochondrial | 1.531087 | 0.0001 |
| DLAT | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex |
1.489361 | 0.014 |
| ETFA | Electron transfer flavoprotein subunit alpha, mitochondrial | 1.485936 | 0.007 |
| OGDH | 2-oxoglutarate dehydrogenase, mitochondrial | 1.452112 | 0.00058 |
| GOT2 | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) |
1.415794 | 0.0046 |
| PGK1 | Phosphoglycerate kinase 1 | 0.699842 | 0.0071 |
| NDUFV1 | NADH dehydrogenase (Ubiquinone) flavoprotein 1 | 0.671429 | 0.016 |
| MCPT1 | Mast cell protease 1 | 0.64121 | 0.0058 |
| SPTAN1 | Spectrin alpha chain | 0.629506 | 1.4E–08 |
| DPP7 | Dipeptidyl peptidase 2 OS=Rattus norvegicus | 0.588844 | 0.00033 |
| ACSL1 | Long-chain-fatty-acid--CoA ligase 1 | 0.579429 | 0.00091 |
| ALDOA | Fructose-bisphosphate aldolase A | 0.535797 | 0.000078 |
| CKM | Creatine kinase M-type | 0.496592 | 0.00078 |
| NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | 0.489779 | 0.014 |
| VIM | Vimentin OS=Rattus norvegicus | 0.445656 | 0.00065 |
| VCL | Vinculin | 0.440555 | 0.022 |
| HSPA8 | Heat shock cognate 71 kDa protein | 0.414954 | 0.00075 |
| PYGM | Phosphorylase, glycogen, muscle | 0.401791 | 0.00035 |
| GOT1 | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) |
0.394457 | 0.0011 |
| BDH1 | D-beta-hydroxybutyrate dehydrogenase, mitochondrial | 0.338065 | 0.000098 |
| TRIM72 | Tripartite motif-containing protein 72 | 0.328852 | 1E–10 |