Table 1. Affinities of Prp8 fragments to full-length Brr2 proteins.

hPrp8 fragment	Kd (nM)	yPrp8 fragment	Kd (nM)	Type of RP13-linked mutation
hPrp8Jab1	7.7	yPrp8Jab1	7.6	-
hPrp8Jab1-Q2321stop	3.2	-	-	III
-	-	yPrp8Jab1-ΔC16	11.1	-
hPrp82300–2335	3150.0	yPrp82378–2413	930.0	-
hPrp8Jab1-R2310G	81.3	-	-	II
hPrp8Jab1-R2310K	46.0	-	-	II
hPrp8Jab1-F2314L	63.5	-	-	II
hPrp8Jab1-Y2334N	20.0	-	-	III

For experimental details, see legend to Figure 4.