Figure 6.
Intertumour heterogeneity of gene expression profiles associated with cellular processes and disease progression. Unsupervised hierarchical clustering showing pair-wise correlations of a panel of gene signature scores across primary breast tumour tissue samples (234 patients). Representative signatures are indicated for each cluster: T-cells, B-cells and dendritic cells, Immune1*, Motility, stem-cell-like, tumour growth factor β (TGFβ) response, RAS*, Stroma2*, GGI*, Gene70*, MYC* (*signature curated by Ignatiadis et al112). Recent studies report expression-based prognostic and predictive stratification of primary breast tumours, which are phenotypically similar according to current clinical methods.111,113,114 Images should be viewed in the online format.