Table 4.
Effect of MPBL in hindpaw licking in the formalin test in mice
| Groups | Dose (mg/kg) | Early phase (Sec) | % protection | Late phase (Sec) | % protection |
|---|---|---|---|---|---|
| Group-I | Vehicle | 34.16 ± 1.38 | - | 47.0 ± 1.03 | - |
| Group-II | 10 | 16.83 ± 0.90* | 50.73 | 19.83 ± 0.70* | 57.80 |
| Group-III | 100 | 27.5 ± 0.76* | 19.51 | 21.5 ± 0.95* | 54.25 |
| Group-IV | 200 | 18.00 ± 0.65* | 47.31 | 20.67 ± 1.46* | 56.02 |
Values are mean±SEM, (n=5);
*
p<0.05 as compared to vehicle control (one-way ANOVA followed by Dunnett’s test). Group I animals received vehicle (1% Tween 80 in water), Group II received diclofenac Na 10 mg/kg body weight, Group III and Group IV were treated with 100 and 200 mg/kg body weight (p.o.) of the MPBL, respectively.